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AHRQ Mentored Research Scientist Career Development Award (K01)

NIH Funding Opportunities - Tue, 12/03/2019 - 08:15
Funding Opportunity PA-20-067 from the NIH Guide for Grants and Contracts. The primary purpose of the AHRQ Mentored Research Scientist Career Development Awards (K01) program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's health services research needs. This AHRQ program provides support and protected time to individuals with a research doctoral degree for an intensive, supervised research career development experience in health services research. The K01 award can be used both by individuals who propose to newly embark in heath services research training and those who had a hiatus in their research careers because of illness or family circumstances.
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Chinese Labs Mine DNA to Map Faces With Help From the West

Yahoo Science News feed latest items - Tue, 12/03/2019 - 06:19

TUMXUK, China -- In a dusty city in the Xinjiang region on China's western frontier, the authorities are testing the rules of science.With 1 million or more ethnic Uighurs and others from predominantly Muslim minority groups swept up in detentions across Xinjiang, officials in Tumxuk have gathered blood samples from hundreds of Uighurs -- part of a mass DNA collection effort dogged by questions about consent and how the data will be used.In Tumxuk, at least, there is a partial answer: Chinese scientists are trying to find a way to use a DNA sample to create an image of a person's face.The technology, which is also being developed in the United States and elsewhere, is in the early stages of development and can produce rough pictures good enough only to narrow a manhunt or perhaps eliminate suspects. But given the crackdown in Xinjiang, experts on ethics in science worry that China is building a tool that could be used to justify and intensify racial profiling and other state discrimination against Uighurs.In the long term, experts say, it may even be possible for the Communist government to feed images produced from a DNA sample into the mass surveillance and facial recognition systems that it is building, tightening its grip on society by improving its ability to track dissidents and protesters as well as criminals.Some of this research is taking place in labs run by China's Ministry of Public Security, and at least two Chinese scientists working with the ministry on the technology have received funding from respected institutions in Europe. International scientific journals have published their findings without examining the origin of the DNA used in the studies or vetting the ethical questions raised by collecting such samples in Xinjiang.In papers, the Chinese scientists said they followed norms set by international associations of scientists, which would require that the men in Tumxuk (pronounced TUM-shook) gave their blood willingly. But in Xinjiang, many people have no choice. The government collects samples under the veneer of a mandatory health checkup program, according to Uighurs who have fled the country. Those placed in internment camps -- two of which are in Tumxuk -- also have little choice.Police prevented reporters from The New York Times from interviewing Tumxuk residents, making verifying consent impossible. Many residents had vanished in any case. On the road to one of the internment camps, an entire neighborhood had been bulldozed into rubble.Growing numbers of scientists and human rights activists say the Chinese government is exploiting the openness of the international scientific community to harness research into the human genome for questionable purposes.Already, China is exploring using facial recognition technology to sort people by ethnicity. It is also researching how to use DNA to tell if a person is a Uighur. Research on the genetics behind the faces of Tumxuk's men could help bridge the two.The Chinese government is building "essentially technologies used for hunting people," said Mark Munsterhjelm, an assistant professor at the University of Windsor in Ontario who tracks Chinese interest in the technology.In the world of science, Munsterhjelm said, "there's a kind of culture of complacency that has now given way to complicity."'Warning to Everybody'Sketching someone's face based solely on a DNA sample sounds like science fiction. It isn't.The process is called DNA phenotyping. Scientists use it to analyze genes for traits like skin color, eye color and ancestry. A handful of companies and scientists are trying to perfect the science to create facial images sharp and accurate enough to identify criminals and victims.Maryland police used it last year to identify a murder victim. In 2015, police in North Carolina arrested a man on two counts of murder after crime-scene DNA indicated the killer had fair skin, brown or hazel eyes, dark hair, and little evidence of freckling. The man pleaded guilty.Despite such examples, experts widely question phenotyping's effectiveness. Currently, it often produces facial images that are too smooth or indistinct to look like the face being replicated. DNA cannot indicate other factors that determine how people look, such as age or weight. DNA can reveal gender and ancestry, but the technology can be hit or miss when it comes to generating an image as specific as a face.Phenotyping also raises ethical issues, said Pilar Ossorio, a professor of law and bioethics at the University of Wisconsin-Madison. Police could use it to round up large numbers of people who resemble a suspect, or use it to target ethnic groups. And the technology raises fundamental issues of consent from those who never wanted to be in a database to begin with."What the Chinese government is doing should be a warning to everybody who kind of goes along happily thinking, 'How could anyone be worried about these technologies?'" Ossorio said.With the ability to reconstruct faces, Chinese police would have yet another genetic tool for social control. Authorities have already gathered millions of DNA samples in Xinjiang. They have also collected data from the hundreds of thousands of Uighurs and members of other minority groups locked up in detention camps in Xinjiang as part of a campaign to stop terrorism. Chinese officials have depicted the camps as benign facilities that offer vocational training, though documents describe prisonlike conditions, while testimonies from many who have been inside cite overcrowding and torture.Even beyond the Uighurs, China has the world's largest DNA database, with more than 80 million profiles as of July, according to Chinese news reports."If I were to find DNA at a crime scene, the first thing I would do is to find a match in the 80 million data set," said Peter Claes, an imaging specialist at the Catholic University of Leuven in Belgium, who has studied DNA-based facial reconstruction for a decade. "But what do you do if you don't find a match?"Though the technology is far from accurate, he said, "DNA phenotyping can bring a solution."Ties to EuropeTo unlock the genetic mysteries behind the human face, police in China turned to Chinese scientists with connections to leading institutions in Europe.One of them was Tang Kun, a specialist in human genetic diversity at the Shanghai-based Partner Institute for Computational Biology, which was founded in part by the Max Planck Society, a top research group in Germany.The German organization also provided $22,000 a year in funding to Tang because he conducted research at an institute affiliated with it, said Christina Beck, a spokeswoman for the Max Planck Society. Tang said the grant had run out before he began working with the police, according to Beck.Another expert involved in the research was Liu Fan, a professor at the Beijing Institute of Genomics who is also an adjunct assistant professor at Erasmus University Medical Center in the Netherlands.Both were named as authors of a 2018 study on Uighur faces in the journal Hereditas (Beijing), published by the government-backed Chinese Academy of Sciences. They were also listed as authors of a study examining DNA samples taken last year from 612 Uighurs in Tumxuk that appeared in April in Human Genetics, a journal published by Springer Nature, which also publishes the influential journal Nature.Both papers named numerous other authors, including Li Caixia, chief forensic scientist at the Ministry of Public Security.In an interview, Tang said he did not know why he was named as an author of the April paper, though he said it might have been because his graduate students worked on it. He said he had ended his affiliation with Chinese police in 2017 because he felt their biological samples and research were subpar."To be frank, you overestimate how genius the Chinese police is," said Tang, who had recently shut down a business focused on DNA testing and ancestry.Like other geneticists, Tang has long been fascinated by Uighurs because their mix of European and East Asian features can help scientists identify genetic variants associated with physical traits. In his earlier studies, he said, he collected blood samples himself from willing subjects.Tang said the police approached him in 2016, offering access to DNA samples and funding. At the time, he was a professor at the Partner Institute for Computational Biology, which is run by the Chinese Academy of Sciences but was founded in 2005 in part with funding from the Max Planck Society and still receives some grants and recommendations for researchers from the German group.Beck, the Max Planck spokeswoman, said Tang had told the organization that he began working with the police in 2017, after it had stopped funding his research a year earlier.But an employment ad on a government website suggests the relationship began earlier. The Ministry of Public Security placed the ad in 2016 seeking a researcher to help explore the "DNA of physical appearance traits." It said the person would report to Tang and to Li, the ministry's chief forensic scientist.Tang did not respond to additional requests for comment. The Max Planck Society said Tang had not reported his work with the police as required while holding a position at the Partner Institute, which he did not leave until last year.The Max Planck Society "takes this issue very seriously" said will ask its ethics council to review the matter, Beck said.It is not clear when Liu, the assistant professor at Erasmus University Medical Center, began working with the Chinese police. Liu says in his online resume that he is a visiting professor at the Ministry of Public Security at a lab for "on-site traceability technology."In 2015, while holding a position with Erasmus, he also took a post at the Beijing Institute of Genomics. Two months later, the Beijing institute signed an agreement with the Chinese police to establish an innovation center to study cutting-edge technologies "urgently needed by the public security forces," according to the institute's website.Liu did not respond to requests for comment.Erasmus said that Liu remained employed by the university as a part-time researcher and that his position in China was "totally independent" of the one in the Netherlands. It added that Liu had not received any funding from the university for the research papers, though he listed his affiliation with Erasmus on the studies. Erasmus made inquiries about his research and determined there was no need for further action, according to a spokeswoman.Erasmus added that it could not be held responsible "for any research that has not taken place under the auspices of Erasmus" by Liu, even though it continued to employ him.Still, Liu's work suggests that sources of funding could be mingled.In September, he was one of seven authors of a paper on height in Europeans published in the journal Forensic Science International. The paper said it was backed by a grant from the European Union -- and by a grant from China's Ministry of Public Security.Tang said he was unaware of the origins of the DNA samples examined in the two papers, the 2018 paper in Hereditas (Beijing) and the Human Genetics paper published in April. The publishers of the papers said they were unaware, too.Hereditas (Beijing) did not respond to a request for comment. Human Genetics said it had to trust scientists who said they had received informed consent from donors. Local ethics committees are generally responsible for verifying that the rules were followed, it said.Springer Nature said on Monday that it had strengthened its guidelines on papers involving vulnerable groups of people and that it would add notes of concern to previously published papers.In the papers, the authors said their methods had been approved by the ethics committee of the Institute of Forensic Science of China. That organization is part of the Ministry of Public Security, China's police.On the Frontier With 161,000 residents, most of them Uighurs, the agricultural settlement of Tumxuk is governed by the powerful Xinjiang Production and Construction Corps, a quasi-military organization formed by decommissioned soldiers sent to Xinjiang in the 1950s to develop the region.The state news media described Tumxuk, which is dotted with police checkpoints, as one of the "gateways and major battlefields for Xinjiang's security work."In January 2018, the town got a high-tech addition: a forensic DNA lab run by the Institute of Forensic Science of China, the same police research group responsible for the work on DNA phenotyping.Procurement documents showed the lab relied on software systems made by Thermo Fisher Scientific, a Massachusetts company, to work with genetic sequencers that analyze DNA fragments. Thermo Fisher announced in February that it would suspend sales to the region, saying in a statement that it had decided to do so after undertaking "fact-specific assessments."For the Human Genetics study, samples were processed by a higher-end sequencer made by an American firm, Illumina, according to the authors. It is not clear who owned the sequencer. Illumina did not respond to requests for comment.The police sought to prevent two Times reporters from conducting interviews in Tumxuk, stopping them upon arrival at the airport for interrogation. Government minders then tailed the reporters and later forced them to delete all photos, audio and video recordings taken on their phones in Tumxuk.Uighurs and human rights groups have said authorities collected DNA samples, images of irises and other personal data during mandatory health checks.In an interview, Zhou Fang, the head of the health commission in Tumxuk, said residents voluntarily accepted free health checks under a public health program known as Physicals for All and denied that DNA samples were collected."I've never heard of such a thing," he said.The questions angered Zhao Hai, the deputy head of Tumxuk's foreign affairs office. He called a Times reporter "shameless" for asking a question linking the health checks with the collection of DNA samples."Do you think America has the ability to do these free health checks?" he asked. "Only the Communist Party can do that!"This article originally appeared in The New York Times.(C) 2019 The New York Times Company


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Hotter weather is causing babies to come early. Nearly 70,000 US moms could go into early labor each year by 2100, a study predicts.

Yahoo Science News feed latest items - Tue, 12/03/2019 - 06:02

Women in the US are giving birth up to two weeks earlier than they should due to a spike in extremely hot days, according to a new study.


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Hotter weather is causing babies to come early. Nearly 70,000 US moms could go into early labor each year by 2100, a study predicts.

Yahoo Science News feed latest items - Tue, 12/03/2019 - 06:02

Women in the US are giving birth up to two weeks earlier than they should due to a spike in extremely hot days, according to a new study.


Categories: Science RSS Feeds

Hotter weather is causing babies to come early. Nearly 70,000 US moms could go into early labor each year by 2100, a study predicts.

Yahoo Science News feed latest items - Tue, 12/03/2019 - 06:02

Women in the US are giving birth up to two weeks earlier than they should due to a spike in extremely hot days, according to a new study.


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Support for Small Business Innovation Research (SBIR) to Develop New Technologies for Development and Integration of Novel Components for Open and Closed Loop Hormone Replacement Platforms for T1D Therapy (R43/R44 Clinical Trial Not Allowed)

NIH Funding Opportunities - Mon, 12/02/2019 - 23:20
Funding Opportunity RFA-DK-19-027 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications for funding to perform research leading to the development of new approaches to create devices/components with enhanced accuracy and less patient burden that will represent real advancements regarding safety and effectiveness of glucose control technologies and their integration into open and closed loop hormone replacement systems.
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Findings of Research Misconduct

NIH Funding Opportunities - Mon, 12/02/2019 - 23:13
Notice NOT-OD-20-029 from the NIH Guide for Grants and Contracts
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Cyrus Biotechnology and CRISPR pioneers team up to boost gene-editing therapies

Yahoo Science News feed latest items - Mon, 12/02/2019 - 17:32

Seattle-based Cyrus Biotechnology says it'll collaborate with the Broad Institute of MIT and Harvard on ways to optimize CRISPR gene-editing techniques for use in developing novel human therapeutics. CRISPR has revolutionized genetics by making it easier to modify the DNA coding in the genome, but more needs to be done to address safety concerns for human applications. Cyrus Biotech and the Broad Institute will work on ways to reduce the potential for the body to mount an immune response against CRISPR-based therapies. MIT biochemist Feng Zhang, one of the pioneers in the development of CRISPR, will be the principal investigator… Read More


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TELEMENTAL HEALTH REPORT: How telehealth can help US hospitals and health systems manage the $238 billion mental health crisis

Yahoo Science News feed latest items - Mon, 12/02/2019 - 16:00

This report outlines how the US' mental health crisis falls on health systems, and how they can navigate the costly dilemma with telemental health.


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THE DIGITAL HEALTH ECOSYSTEM: An in-depth examination of the players and tech trends reshaping the future of healthcare

Yahoo Science News feed latest items - Mon, 12/02/2019 - 14:00

Business Insider Intelligence explores the healthcare ecosystem, industry trends driving digital transformation, and where the industry is headed.


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Reminder to AHRQ Grantees that FY2015 Funds will Expire on September 30, 2020

NIH Funding Opportunities - Mon, 12/02/2019 - 10:30
Notice NOT-HS-20-002 from the NIH Guide for Grants and Contracts
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Postbaccalaureate Research Education Program (R25 - Independent Clinical Trial Not Allowed)

NIH Funding Opportunities - Mon, 12/02/2019 - 10:24
Funding Opportunity PAR-20-066 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) provides support to eligible, domestic institutions to develop and implement effective, evidence-informed approaches to biomedical research education and mentoring that will keep pace with the rapid evolution of the research enterprise. NIGMS expects that the proposed research education programs will incorporate extensive research experiences, well-designed courses for skills development, mentoring, cohort building activities, and career development elements to prepare recent baccalaureates from diverse backgrounds to transition into and complete rigorous research-focused doctoral degree programs (e.g., Ph.D. or M.D./Ph.D.) in biomedical fields. This program is limited to applications from doctoral degree-granting research-intensive institutions. This Funding Opportunity Announcement (FOA) does not allow appointed participants to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.
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NHLBI Announces Plan to Fund a Framingham Heart Study Exam for the Generation 3 and Omni 2 Cohorts

NIH Funding Opportunities - Mon, 12/02/2019 - 09:37
Notice NOT-HL-19-732 from the NIH Guide for Grants and Contracts
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NASA's plans for the 2020s include landing humans on the moon, detecting quakes on Mars, and defending Earth from deadly asteroids

Yahoo Science News feed latest items - Mon, 12/02/2019 - 08:43

One year ago, NASA announced it would send astronauts back to the moon. Since then, new spacecraft and telescopes have filled its plans for the 2020s.


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NASA's plans for the 2020s include landing humans on the moon, detecting quakes on Mars, and defending Earth from deadly asteroids

Yahoo Science News feed latest items - Mon, 12/02/2019 - 08:43

One year ago, NASA announced it would send astronauts back to the moon. Since then, new spacecraft and telescopes have filled its plans for the 2020s.


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