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It’s another big win for Morgan Stanley banker Michael Grimes, who has become the go-to adviser for many of Silicon Valley’s largest IPOs. Goldman Sachs Group is also expected to play a role in shepherding Uber through the IPO process, according to the people, who asked not to be identified because the decision hasn’t been made public. Morgan Stanley declined to comment.
Overeating in teenage years could damage the lifespan of future grandsons, a new study suggests. Researchers in Sweden looked back at 9,039 grandparents born between 1874 and 1910, and followed their grandchildren until 2015. After comparing information from harvests, they found that that the grandsons of grandfathers who had eaten well from bountiful harvests during their formative years, were three times more likely to have died from cancer. They were also 50 per cent more likely to have died from all causes, than children whose grandparents grew up in leaner times. While the risk of early death was 10 per cent over the study period overall, it rose to 15 per cent for the descendants of those who ate well. Likewise, cancer deaths rose from two per cent to six per cent. The scientists believe that eating too much may rewrite the genetic code, in a way which could increase the risk of disease for future generations - a process known as transgenerational epigenetic inheritance, which was thought impossible just a few years ago. In Britain 32.4 per cent of children are now overweight or obese by the age of 11, and the figures are worse for boys, with 36 per cent classed in the heaviest categories. Denny Vagero, Professor of Medical Sociology at Stockholm University, said: “We should probably be concerned about over-eating, also in terms of future generations’ health. “We prefer to be very cautious about the actual mechanisms. However, the results are unlikely to be due to confounding from cultural or social factors. We discuss whether new mutations, due to 19th century farming practices, could be the mechanism, but found this less likely. “It is therefore worth exploring further the possibility that there is an epigenetic, male-line, transgenerational mechanism which can be triggered during boys childhood, pre-puberty. “Stephen Frankel in Bristol, in his paper from 1998, showed that children with the highest calorie intake had a doubled cancer mortality risk as adults. We speculate that this effect becomes transgenerational in men.” The study did not find any link between grandmothers and their grandchildren, nor granddaughters and their grandfathers. The team said further research was needed to find out if the genetic code really was changing before they could say that the food intake was definitely causing an epigenetic change. The research was published in Nature Communications.
Ministers from nations imperilled by rising seas and temperatures on Tuesday called for drastic action at UN climate talks deadlocked over a refusal by big polluters to embrace landmark environmental data. The COP24 summit in Poland is scheduled to finish at the end of the week but delegates are still worlds apart when it comes to agreeing on a rulebook making good on the promises nailed down in the 2015 Paris climate accord.
Warming and melting Arctic has 'cascading effects' around the globe, 2018 Arctic Report Card says
Bees with tiny electronic devices on their backs could sound like a researcher’s dream come true, or like a science-fiction novelist’s nightmare come true. Shyam Gollakota, an associate professor at the University of Washington’s Paul G. Allen School of Computer Science and Engineering, prefers the optimistic view. He and his colleagues at UW have found a way to pack environmental sensors into a backpack small enough for a bumblebee to carry. The approach, which the UW team calls “Living IoT,” brings significant advantages over the human-made kind of drones. “Drones can fly for maybe 10 or 20 minutes before they… Read More
Children account for a third of Ebola cases in an outbreak of the disease in the Democratic Republic of Congo, with hundreds orphaned or isolated, the United Nations said on Tuesday. Nearly 300 people have died from the highly contagious disease since August in the restive east around the city of Beni. The UN children's agency UNICEF said the organisation and its partners had identified more than 400 children who have been orphaned or isolated during the outbreak.
Two Russian cosmonauts took a spacewalk on Tuesday seeking to resolve the mystery of a small hole found in the side of a craft docked at the International Space Station. Russia's space agency Roscosmos has ruled out a manufacturing defect causing the 2 mm-wide hole found in August on the Russian Soyuz capsule, but NASA has sought to dampen speculation of sabotage. Oleg Kononenko and Sergey Prokopyev's six-hour-long spacewalk began at 1600 GMT, a live broadcast by Roscosmos showed.
As the hearing began, the heads of both political parties led with questions about Google’s data collection. Republican Bob Goodlatte asked how much personal information Google absorbs via its Android mobile software. Pichai stressed that users opt in to certain data-tracking features, giving the example of fitness apps that measure steps.
BAGHDAD (Reuters) - Iraqi Prime Minister Adel Abdul Mahdi said on Tuesday he would send a delegation to the United States to seek an exemption from sanctions against Iran that would allow Baghdad to keep importing gas from Tehran. "The American side is cooperating with Iraq to find solutions that would remove pressure on Iraq because the (Iranian) gas is linked to a very sensitive issue which is electricity," Abdul Mahdi told a news conference. (Reporting by Ahmed Rasheed; Writing by Ahmed Aboulenein; Editing by Gareth Jones)
Earth's Mysterious 'Deep Biosphere' Is Home to Millions of Undiscovered Species, Scientists Say
Life on Earth takes billions of shapes, but to see most of them you'll have to dig deep below the planet's surface. For the past 10 years, that's what the scientists of the Deep Carbon Observatory (DCO) have been doing. Composed of more than 1,000 scientists from 52 countries around the world, this group of scientists maps the weird, wild life of Earth's "deep biosphere" — the mysterious patchwork of underground ecosystems that exists between Earth's surface and its core.
A warming climate is thawing permafrost and up to 70 percent of infrastructure in the Arctic region is at risk, including key oil and gas fields, a new study said Wednesday. Researchers used detailed information on infrastructure across the Northern Hemisphere permafrost zone to model with unprecedented detail just how many buildings, roads, railways and other construction could be at risk by 2050. "Especially that around 70 percent of current infrastructure in the permafrost domain is in areas with high potential for thaw of near-surface permafrost," he told AFP.
Doctors and experts have long warned against eating too much red meat for heart health. In fact, the American Heart Association (AHA) recommends only eating lean meat such as chicken or fish without the skin because they are lower in saturated fat and saturated fat raises cholesterol and could lead to heart disease.
Darwesh Khan's trouble began with just a little itching in his hands and what he believed was a pimple on his cheek. The labourer thought little of either until painful ulcers began to grow over his fingers making it difficult to move them. At the same time, another disfiguring lesion started to blossom and spread under his right eye. Fearing he would be unable to work if they got worse, he sought medical advice. But in his home of Charsadda district in Pakistan's northern east, that treatment was of little use, even if it cost a large chunk of his meagre wages. After shelling out $100 for medicine from private doctors, the sores kept getting bigger. “Four months ago it became very serious,” he explained. “I spent a lot of money with no improvement.” The 41-year-old had caught cutaneous leishmaniasis, a parasitic disease spread by blood-sucking sandflies that causes skin lesions in up to a million people around the world each year. Darwesh Khan's Leishmaniasis infection began with a little itching in his hands and what he believed was a pimple on his cheek Credit: Saiyna Bashir /The Telegraph While the disease is not fatal, it causes gruesome, lifelong scarring that can disfigure faces and limbs. Because it is not deadly, and because its victims are normally the rural poor, the disease is also neglected. Many health workers in Pakistan do not know how to recognise it, or how to treat it, but that may soon have to change. The disease has long been endemic in the remote districts of Khyber Pakhtunkhwa and Baluchistan, but it appears to be spreading and becoming more common, not just in Pakistan, but around the world. “It is increasing,” said Suzette Kämink, who researches the disease for the Doctors Without Borders (MSF) aid agency. “Increasing in places where we did see them before, but also we see cases now in different areas where we have not seen them before.” Factfile | Leishmaniasis Exact numbers for cases and how they are rising are hard to come by in Pakistan. Doctors must notify local authorities of cases of cutaneous leishmaniasis, but reporting is patchy. Reasons for the increase are also unclear. Afghan refugees have brought cases with them in the past, but these are not thought to be responsible for the recent increase, Ms Kämink said, because they have been crossing the border to flee the war for decades. Climate change may be a factor. The sandfly which carries the protozoan Leishmania parasites is very susceptible to temperature. Small fluctuations can mean that the parasite spreads in areas it previously found inhospitable. Changes in rainfall or humidity can also alter the flies' range. The weals start appearing three months after a patient is bitten. They will heal if left untreated, which gives rise to one of the conditions nicknames, saldana or one-year-blister. But that process takes months and leaves deep scarring. Patients wait outside the Cutaneous Leishmaniasis Treatment Centre at Naseerullah Babar Memorial Hospital Credit: Saiyna Bashir /The Telegraph “Somehow it is neglected because people don't die from this disease, but they are quite affected by the big scars or big wounds on their faces,” Ms Kämink said. “The main disadvantage of this disease is psychological, especially for females with lesions on their face. They are rejected by society,” added Dr Parvez Khan, medical activity manager at the clinic. Those struck with the disease also often fall prey to medical quacks, or at best are given incomplete or expired doses of medicine. The only effective drug has to be imported into Pakistan by the World Health Organisation and MSF. The need for treatment is obvious at MSF's clinic in Peshawar's Naseerullah Babar Khan Memorial Hospital. Since opening in May, the numbers attending have climbed steadily each month. It has received more than 1,200 cases and is operating flat out. Khandad Khan, a soldier in the military, is treated for his Leishmaniasis infection Credit: Saiyna Bashir /The Telegraph Many travel for hours to reach it and receive a course of 20 to 30 daily injections free of cost. Khandad Khan, a lance corporal in the Frontier Constabulary, said between 60 and 70 of his colleagues stationed at Darazinda in Dera Ismail Khan had been struck with the parasite. “It's very difficult to walk,” he told The Telegraph, wincing as a nurse changed the dressing on an open ulcer on a big toe. “The flies don't bite the locals, they just bite us.” A 10-year-old named Mohammad from Bannu district was delighted that his ulcer on his nose was gradually receding when The Telegraph visited the clinic last month. “I noticed a small pimple on my nose and I didn't know what it was. Then it gradually got bigger and bigger. Ten-year-old Muhammad said his infection is beginning to recede after treatment Credit: Saiyna Bashir /The Telegraph “My friends told me my nose was increasing in size day by day and they teased me. My mother also has the same problem in her hands,” he explained. Darwesh Khan's course of injections have reversed his own infection and he is happy to show off his ulcer-free fingers. But sparing the time to attend the clinic for dozens of injections can be a heavy burden for day labourers like him. Health officials hope to set up smaller sub centres closer to patients, with the first in Nowshera. “They cannot afford to spare the time to come here. I have had one patient who begged me to give him all the injections at once,” explained one hospital official. Newsletter promotion - global health security - end of article Protect yourself and your family by learning more about Global Health Security
"Arctic air temperatures for the past five years have exceeded all previous records since 1900," according to the annual NOAA study, the 2018 Arctic Report Card, which said the year was second only to 2016 in overall warmth in the region. It marks the latest in a series of warnings about climate change from U.S. government bodies, even as President Donald Trump has voiced skepticism about the phenomenon and has pushed a pro-fossil fuels agenda. The study said the Arctic warming continues at about double the rate of the rest of the planet, and that the trend appears to be altering the shape and strength of the jet stream air current that influences weather in the Northern Hemisphere.
NIH Funding Opportunities
- Notice of Expiration of PA-18-471 "Innovative Questions in Symptom Science and Genomics (R15 Clinical Trial Not Allowed)"
- Advance Notice: Streamlining the Certifications and Representations Process and Phasing out the SF-424B
- NIDCR Mentoring Network to Support a Diverse Dental, Oral and Craniofacial Research Workforce (UE5 Clinical Trials Not Allowed)
- Limited Competition: Clinical and Translational Science Award (CTSA) Program: Exploratory Collaborative Innovation Awards (R21 Clinical Trial Optional)
- Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative Innovation Award, (U01 Clinical Trial Optional)