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Gilead Sciences Inc's experimental drug aimed at treating fatty liver disease NASH failed to meet the main goal of a late-stage study on Thursday, two months after it failed another. The trial was testing the drug, selonsertib, in patients with a form of fibrosis, called bridging, caused by NASH or Nonalcoholic Steatohepatitis. The drug did not show an improvement in fibrosis symptoms, Gilead said.
Three years ago, however, the 39-year-old Ugandan was abandoned by her husband, leaving her to support their surviving 38 children alone. It was just the latest setback in a life marred by tragedy for Nabatanzi, who lives with her children in four cramped houses made of cement blocks and topped with corrugated iron in a village surrounded by coffee fields 50 km (31 miles) north of Kampala.
One of the tools that the Paris Fire Brigade used to contain the Notre-Dame blaze was a firefighting robot. Developed by Shark Robotics, Colossus is designed to be deployed in environments that are too hot and dangerous for human firefighters to operate. Read more...More about Robots, Mashable Video, Robot, Fire, and Firefighters
Brent oil rose above $75 per barrel on Thursday for the first time this year as quality concerns forced the suspension of some Russian crude exports to Europe while the United States prepared to tighten sanctions on Iran. Brent crude futures were at $75.24 by 1156 GMT, up 67 cents. U.S. attempts to drive Iranian oil exports down to zero also boosted prices.
Since 2014, Emerson has backed more than 30 startups, according to research firm PitchBook, investing in a range of novel companies making everything from floating data centers to supersonic aircraft. Started more than a decade ago, Emerson Collective may be the strangest entity in Silicon Valley: part charitable foundation, part venture capital firm, operating in near-total secrecy, despite being run by one of the most famous women in business. Like the philanthropic arm of Mark Zuckerberg, Emerson is a limited liability company. LLCs aren’t subject to the same reporting rules as nonprofits and can more easily invest in for-profit companies. Emerson does that—putting money into companies that it says fit within the parameters of its philanthropic mission—with some success.
Sudan could face a counter coup if military rulers and the opposition do not reach agreement on a transition of power, leading opposition figure Sadiq al-Mahdi said on Thursday. Mahdi said he believed Sudan's military council would hand over power to civilians if the current stalemate were broken. "I think their intentions are good," he said of the army generals who toppled President Omar Hassan al-Bashir on April 11, three decades after he himself seized power in a coup, and then formed the Transitional Military Council (TMC).
U.S drugmaker Bristol-Myers Squibb Co, which is set to buy biotechnology company Celgene Corp for $74 billion, posted slightly better-than-expected first-quarter earnings on Thursday on strong sales of its blockbuster blood thinner Eliquis. Bristol said it still expects the deal to close in the third quarter, after its shareholders voted to approve the deal earlier this month despite a campaign by activist hedge fund Starboard Value LP to scuttle it.
More than ten firms raised their price targets on the stock, while UBS upgraded its view, reinforcing the dominance of Facebook bulls on Wall Street, where roughly 80 percent of the analyst ratings are buy-equivalents. The average price target currently stands at around $212, according to data compiled by Bloomberg, up from $198 on Tuesday.
China aims to make the Belt and Road initiative sustainable and prevent debt risks, its finance minister said on Thursday, seeking to allay criticism that the infrastructure plan to boost trade and investment creates a heavy burden for some nations. The policy championed by Chinese President Xi Jinping has become mired in controversy, with some partner nations bemoaning the high cost of projects, though China has repeatedly said it is not seeking to trap anyone with debt. Finance minister Liu Kun, speaking at a forum to kick off a three-day Belt and Road summit in Beijing, said China will establish an analysis framework on debt sustainability for Belt and Road projects to "prevent and resolve debt risks".
While all three companies have held the title of largest U.S. stock at some point in 2019, Apple is the only one to have spent much time above the $1 trillion valuation. Apple will get its chance to rejoin the 13-digit club when it releases earnings on Tuesday.
DURBAN/JOHANNESBURG (Reuters) - Almost 70 people have been killed in South Africa after torrential rains along the eastern coast, an official said on Thursday, and rescuers are still recovering bodies. KwaZulu-Natal province, where most of the deaths occurred after the downpours led to flooding and mudslides, has heavy rain every year, but they rarely kill so many people in such a short space of time. The number of people killed was "approaching 70", Lennox Mabaso, a spokesman for the provincial Cooperative Governance and Traditional Affairs department, said by phone.
Japanese scientists have succeeded in creating what they called the first-ever artificial crater on an asteroid, a step towards shedding light on how the solar system evolved, the country's space agency said Thursday. The announcement comes after the Hayabusa2 probe fired an explosive device at the Ryugu asteroid early this month to blast a crater in the surface and scoop up material, aiming to reveal more about the origins of life on Earth. Yuichi Tsuda, Hayabusa2 project manager at the Japanese space agency (JAXA), told reporters they confirmed the crater from images captured by the probe located 1,700 metres (5,500 feet) from the asteroid's surface.
Last year humanity destroyed an expanse of tropical forest nearly the size of England, the fourth largest decline since global satellite data become available in 2001, researchers reported Thursday. Almost a third of that area, some 36,000 km2, was pristine primary rainforest, according to the annual assessment from scientists at Global Forest Watch, based at the University of Maryland. Despite a slew of counter-measures at both the national and international level, deforestation has continued largely unabated since the beginning of the century.
After troublesome drones infiltrated London’s Gatwick airport late last year, disrupting passenger flights and costing potentially millions of pounds in revenue, that was the instinctive question posed by the watching world. The U.S. Federal Aviation Administration announced in early 2018 it had logged more than one million registered drones, and Goldman Sachs Group Inc. predicts that by 2020, there will be 7.8 million shipments of consumer drones--an industry worth $3.3 billion in revenue. An offshoot of Alphabet Inc.’s Google, Wing Aviation LLC, on Tuesday became the first drone operator to receive government approval as an airline, enabling it to begin routine deliveries in U.S. skies.
(Bloomberg) -- Last quarter, Amazon.com Inc. hinted that spending on investments such as data centers and warehouses would rise in 2019. The magnitude of those outlays is one of the biggest questions investors have ahead of Amazon’s first-quarter earnings on Thursday afternoon.
The second largest Emperor penguin colony on Earth has suffered a "catastrophic" breeding failure after nearly all chicks born over three years died as their icy Antarctic habitat shrinks, researchers said Thursday. The British Antarctic Survey (BAS) used satellite imagery to study the behaviour of the Halley Bay colony in the Weddell Sea due south of Cape Hope, which normally sees up to 25,000 penguin pairs mate each year. The BAS said the colony at Halley Bay has "all but disappeared".
The Extinction Rebellion group has caused mass disruption across London, blocking Marble Arch, Oxford Circus and Waterloo Bridge, smashing a door at the Shell building and shocking lawmakers with a semi-nude protest in parliament. On Thursday, they turned their attention to London's financial district, known as the City - home to more international banks than any other and the global center for foreign exchange trading. In streets beside the Bank of England, around 20 activists blocked the road singing Bob Marley's "One Love".
LONDON (AP) — Environmental activists who have brought disruption to the British capital for more than a week blocked the main entrance to the London Stock Exchange on Thursday, gluing themselves to the doorway while wearing LED displays reading "climate emergency."
Operating profit was 29.7 billion yen ($266 million) in the three months ended March, compared with the 36 billion yen average of estimates compiled by Bloomberg. For the current fiscal year, operating profit will be 260 billion yen, below the 350.2 billion yen expected by analysts. Shares have rallied this year on optimism that a cheaper version of the Switch, a stronger lineup of games and a potential entry into China will help overcome last year’s missteps and broaden Nintendo’s customer base beyond dedicated fans.
NIH Funding Opportunities
- Registration Open for the ICARE Academy on September 10-11, 2019, in Alexandria, VA
- Microbiome and Aging: Impact on Health and Disease (R01 Clinical Trial Not Allowed)
- Center of Excellence for Natural Product Drug interaction Research (U54, Clinical Trial Required)
- Preclinical Screening for Natural Product Drug Interactions (Clinical Trial Not Allowed, R21)
- Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76 Independent Clinical Trial Not Allowed)