NIH Funding Opportunities

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Weekly Funding Opportunities and Policy Notices from the National Institutes of Health.
Updated: 1 hour 58 min ago

Processing and Presentation of Non-Conventional MHC Ligands (R21 Clinical Trial Not Allowed)

Tue, 11/13/2018 - 09:18
Funding Opportunity PA-19-066 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to determine antigen processing and presentation mechanisms used in the generation of novel peptidic and non-peptidic ligands and to determine the contribution of these unique antigenic ligands to protective immune responses against infectious disease pathogens and/or vaccines; pathogen-associated immune pathogenesis; and/or limit progression or induction of immune-mediated diseases. These studies may facilitate the development of novel tools and reagents to advance design of immune-based therapeutics and vaccines.
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Processing and Presentation of Non-Conventional MHC Ligands (R01 Clinical Trial Not Allowed)

Tue, 11/13/2018 - 09:18
Funding Opportunity PA-19-067 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to characterize antigen processing and presentation mechanisms used in the generation of novel peptidic and non-peptidic ligands presented by classical and non-classical MHC class I and class II molecules, and to determine the contribution of these unique antigenic ligands to: protective immune responses to infectious pathogens and/or vaccines; pathogen-associated immune pathogenesis; and/or in the induction/progression or prevention of immune-mediated diseases. These studies may facilitate the development of novel tools and reagents to advance design of immune-based therapeutics and vaccines.
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Medical Simulators for Practicing Patient Care Providers Skill Acquisition, Outcomes Assessment and Technology Development (R01 Clinical Trial Not Allowed)

Tue, 11/13/2018 - 00:52
Funding Opportunity PA-19-065 from the NIH Guide for Grants and Contracts. The purpose of the Funding Opportunity Announcement (FOA) is to promote the assessment and further development of simulation technologies intended to improve patient safety and healthcare outcomes provided by practicing patient care providers and experienced (not trainee) physicians. The FOA seeks applications directed toward three areas of research: 1) Skill Acquisition: to evaluate strategies and protocols for simulation-based methods for skill acquisition and maintenance by experienced clinicians; 2) Outcomes Assessment: to assess the relationship of simulation-based assessments of skills demonstrated by experienced clinicians with the quality of clinical care delivered by those clinicians, and to identify strategies to increase the quality of simulation-based assessments of skills; and 3) Technology Development: to develop virtual coaches by incorporating intelligent technologies into existing simulators to provide adaptive, cognitive assistance to coach experienced practitioners in retaining, retraining and improving performance levels in the context of the user environment (and physiological system as appropriate).
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Single-Cell Multi-Omics of HIV Persistence (R01 Clinical Trial Not Allowed)

Tue, 11/13/2018 - 00:33
Funding Opportunity RFA-AI-18-053 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) will support basic science research to address outstanding questions in HIV latency and persistence by leveraging state-of-the-art single-cell multi-omics approaches. The goal is to interrogate HIV persistence with high molecular detail and resolution to better understand HIV persistence at the single-cell level. Emphasis will be on multi-omics or multiplex approaches integrating cutting-edge single-cell analysis technologies.
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Notice of Legislative Mandates in Effect for FY 2019

Fri, 11/09/2018 - 10:14
Notice NOT-OD-19-030 from the NIH Guide for Grants and Contracts
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Mechanism for Time-Sensitive Drug Abuse Research (R21 Clinical Trial Optional)

Fri, 11/09/2018 - 10:07
Funding Opportunity PAR-19-064 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) will support pilot, feasibility or exploratory research in 5 priority areas in substance use epidemiology and health services, including: 1) responses to sudden and severe emerging drug issues (e.g. the ability to look into a large and sudden spike in opioid or synthetic cannabinoid use/overdoses in a particular community); 2) responses to emerging marijuana trends and topics related to the shifting policy landscape; 3) responses to unexpected and time-sensitive prescription drug abuse research opportunities (e.g., new state or local efforts); 4) responses to unexpected and time-sensitive medical system issues (e.g. opportunities to understand addiction services in the evolving health care system); and 5) responses to unexpected and time-sensitive criminal or juvenile justice opportunities (e.g. new system and/or structural level changes) that relate to drug abuse and access and provision of health care service. It should be clear that the knowledge gained from the proposed study is time-sensitive and that an expedited rapid review and funding are required in order for the scientific question to be answered (i.e. an imminent policy change will not allow for standard review and funding timeline).
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Data Coordinating Center for the Diabetic Foot Consortium (U24 Clinical Trial Not Allowed)

Thu, 11/08/2018 - 10:04
Funding Opportunity RFA-DK-18-010 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for a Data Coordinating Center (DCC) that will support the Diabetic Foot Consortium (DFC) for clinical research on diabetic foot ulcers. The first studies will validate biomarkers that predict healing or response to therapy and assess infection or recurrence risk. Future research may involve clinical trials and studies on the pathophysiology of diabetic foot ulcers. Given the clinical complexity of diabetic wound healing, the applicant must have experience serving as the DCC on clinical studies of diabetic foot ulcers. The DCC will provide overall project coordination, administration, quality control, data management, and biostatistical support.
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Investigator Initiated Research in Computational Genomics and Data Science (R43/R44 Clinical Trial Not Allowed)

Thu, 11/08/2018 - 09:44
Funding Opportunity PAR-19-061 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts aimed towards commercial product development in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. This FOA supports genomics research developing innovative analytical and computational commercial products, methodologies, and approaches, early stage development of commercial tools and software, and refinement or hardening of software and tools of high value to the biomedical genomics community. Work supported under this FOA should be enabling for genomics and be generalizable or broadly applicable across diseases and biological systems.
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Notice of Expiration of PA-18-474 "Self-Management for Health in Chronic Conditions (R15 Clinical Trial Not Allowed)"

Thu, 11/08/2018 - 01:31
Notice NOT-NR-18-023 from the NIH Guide for Grants and Contracts
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Notice of Change in Receipt Date for the Emerging Global Leader Award (K43) (Independent Clinical Trial Not Allowed)

Thu, 11/08/2018 - 01:12
Notice NOT-TW-18-009 from the NIH Guide for Grants and Contracts
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Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21 Clinical Trials Optional)

Wed, 11/07/2018 - 10:33
Funding Opportunity PAR-19-059 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) supports planning, design and initial pilots for locally relevant and catalytic research on non-communicable diseases (NCDs) or injury in low and middle-income countries (LMICs). Research addressing multiple NCDs and their risk factors and research addressing NCDs as comorbidities for/with infectious diseases including HIV/AIDS is encouraged. Scientists in the United States (U.S.) or upper middle income countries (UMICs) are eligible to partner with scientists in LMIC institutions. Income categories used are defined by the World Bank at http://data.worldbank.org/about/country-classifications/country-and-lending-groups. Pilot activities and research are expected to inform the development of more comprehensive research programs that contribute to the long-term goals of building sustainable research capacity in LMICs to address NCDs and injury throughout life and to lead to diagnostics, prevention, treatment and implementation strategies. The proposed work may also contribute to developing a base for research networking and evidence-based policy beyond the specific research project.
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