NIH Funding Opportunities

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Weekly Funding Opportunities and Policy Notices from the National Institutes of Health.
Updated: 4 hours 55 min ago

Oversight and Monitoring of Clinical Research funded by the NIMH

Mon, 04/08/2019 - 09:07
Notice NOT-MH-19-027 from the NIH Guide for Grants and Contracts
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Building Interdisciplinary Research Careers in Women's Health (BIRCWH); K12 Clinical Trial Optional

Mon, 04/08/2019 - 08:58
Funding Opportunity RFA-OD-19-020 from the NIH Guide for Grants and Contracts. The NIH Office of Research on Women's Health (ORWH) and participating NIH Institutes and Centers invite institutional career development award applications for Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Career Development Programs, hereafter termed "Programs". Programs will support mentored research career development of junior faculty members, known as BIRCWH Scholars, who have recently completed clinical training or postdoctoral fellowships, and who will be engaged in interdisciplinary basic, translational, behavioral, clinical, and/or health services research relevant to the health of women and, where appropriate, the use of both sexes to better understand the influence of sex as a biological variable on health and disease. This Funding Opportunity Announcement (FOA) allows appointment of Scholars proposing to serve as the lead investigator of an independent clinical trial; or proposing a separate ancillary clinical trial; or proposing to gain research experience in a clinical trial led by another investigator, as part of their research and career development. The clinical trial must be a NIH-defined clinical trial. Scholars may also propose fundamental research or human subjects research that is not a clinical trial.
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SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)

Mon, 04/08/2019 - 08:40
Funding Opportunity RFA-CA-19-047 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) applications from small business concerns (SBCs) that seek additional funding to support the next stage of development for projects that were previously funded under SBIR or STTR Phase II awards from any Federal agency. Projects proposed in response to this FOA must be applicable to one of the following areas: (1) cancer therapeutics; (2) cancer imaging technologies, interventional devices, and/or in vivo diagnostics; or (3) in vitro and ex vivo cancer diagnostics and prognostics. The purpose of this FOA is to facilitate the transition of SBIR or STTR Phase II projects to the commercialization stage. This FOA is expected to promote partnerships between Federally-funded SBIR or STTR Phase II awardees and third-party investors and/or strategic partners to facilitate and accelerate the capital-intensive steps that are required to commercialize new products and services. Applicants must submit a Commercialization Plan, which should include details on any independent third-party investor funding that has already been secured or is anticipated during the Phase IIB Bridge Award project period. It is expected that the level of this independent third-party funding will be equal to or greater than the NCI funds being requested throughout the Phase IIB Bridge Award project period. Proposed projects may address preclinical and/or clinical stages of technology development. Clinical trials may be proposed as appropriate but are not required
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BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed)

Mon, 04/08/2019 - 07:49
Funding Opportunity RFA-MH-20-135 from the NIH Guide for Grants and Contracts. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate tools and resources to facilitate the detailed analysis of brain microconnectivity. Novel and augmented techniques are sought that will ultimately be broadly accessible to the neuroscience community for the interrogation of microconnectivity in healthy and diseased brains of model organisms and humans. Development of technologies that will significantly drive down the cost of connectomics would enable routine mapping of the microconnectivity on the same individuals that have been analyzed physiologically, or to compare normal and pathological tissues in substantial numbers of multiple individuals to assess variability. Advancements in both electron microscopy (EM) and super resolution light microscopic approaches are sought. Applications that propose to develop approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged. Proof-of-principle demonstrations and/or reference datasets enabling future development are welcome, as are improved approaches for automated segmentation and analysis strategies of neuronal structures in EM images.no
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Oral Health in People Living with HIV and Additional Non-Communicable Diseases (R01 Clinical Trial Not Allowed)

Mon, 04/08/2019 - 07:35
Funding Opportunity RFA-DE-20-001 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) encourages research to address gaps in our knowledge of the oral health status of people living with HIV (PLWH) with an emphasis on PWLH who also have non-communicable diseases (NCDs). It supports efforts to understand the combined effects of HIV, antiretroviral therapy (ART), and NCDs on oral health, and it encourages identification of approaches for prevention and treatment of oral diseases and assessment of treatment outcomes in PLWH with or without NCDs. These efforts could help to generate evidence for oral health treatment guidelines tailored to the needs of dental patients with HIV.
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Paul Calabresi Career Development Award for Clinical Oncology (K12 Clinical Trial Optional)

Mon, 04/08/2019 - 01:33
Funding Opportunity PAR-19-242 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) allows appointment of Scholars proposing to serve as the lead investigator of an independent clinical trial; or proposing a separate ancillary study to an existing trial; or proposing to gain research experience in a clinical trial led by another investigator, as part of their research and career development.
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Accelerating Medicine Partnership in Parkinsons disease (AMP PD) unbiased proteomics biofluid analysis (U01 Clinical Trials Not Allowed)

Fri, 04/05/2019 - 01:15
Funding Opportunity RFA-NS-19-028 from the NIH Guide for Grants and Contracts. The purpose of the FOA is to support unbiased proteomics analysis of matched longitudinal CSF and plasma samples from the Accelerating Medicine Partnership in Parkinson's disease (AMP PD) cohorts using a data independent acquisition (DIA) mass spectrometry platform, with the ultimate goal of identifying PD biomarkers for diagnosis, prognosis and progression. Proteomics data and workflows generated through this initiative will be broadly shared with the research community through the AMP PD Knowledge Portal to enable additional analyses and data integration across the various datatypes available through AMP PD. The proteomics analysis will be staged to include identification of pre-analytical variables, that will inform the optimal handling of 4,500 CSF and plasma samples.
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Stimulating Urology Interdisciplinary Team Opportunity Research (SUITOR) (R01 Clinical Trial Optional)

Fri, 04/05/2019 - 00:56
Funding Opportunity PAS-19-241 from the NIH Guide for Grants and Contracts. The Stimulating Urology Interdisciplinary Team Opportunity Research (SUITOR) program is intended to promote innovative, high quality, interdisciplinary research relevant to the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK here invites investigator-initiated research project grant applications (R01s) in specific areas of basic, translational and clinical research in specific benign urologic conditions and diseases where needs and opportunities for progress are particularly timely. Specific research topic areas supported by the SUITOR program, as outlined below, will change over time and will be updated annually through the NIH Guide to Grants and Contracts.
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Salary Limitation on AHRQ FY2019 Grants, Cooperative Agreements, and Contracts

Fri, 04/05/2019 - 00:23
Notice NOT-HS-19-013 from the NIH Guide for Grants and Contracts
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Targeting Inflammasomes in Substance Abuse and HIV (R01 Clinical Trial Not Allowed)

Thu, 04/04/2019 - 11:20
Funding Opportunity RFA-DA-19-039 from the NIH Guide for Grants and Contracts. Neuroinflammation triggered by brain trauma, neurodegenerative diseases and neurotoxicant-induced CNS disorders initiates CNS innate immune responses that activate inflammasomes. Inflammasomes are high molecular weight complexes in the cytosol of stimulated immune cells that mediate the activation of inflammatory cascades. In response to insults, Nod-like receptors (NLRs) recruit adaptor proteins and caspase-1 to assemble inflammasomes and process the release of pro-inflammatory cytokines IL-1?, IL-18 and IL-33. Recent evidence suggests that chronic drug exposure, i.e., cocaine, methamphetamine and morphine, can induce inflammasome activation primarily mediated by NLRP3 within microglia. Additionally, emerging data suggest that HIV-1 infection can also prime inflammasome activation. Drug abuse, especially in association with HIV-1 infection, induces ROS production, impairs blood brain barrier integrity, and promotes monocyte transmigration. These upstream events exert synergistic effects that prime oligomerization and activation of inflammasome and release of pro-inflammatory cytokine IL-1?. The scientific objective of this research is to delineate the role of inflammasomes in neuropathology produced by chronic drug exposure and HIV infection. Understanding the involvement of inflammasome in the immune activation may help identify molecular markers and immune cells associated with HIV-1 disease progression among substance abuse populations, and identify novel targets for intervention to treat neuroinflammation and immune dysregulation aroused in these processes.
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Rare Disease Cohorts in Heart, Lung, Blood and Sleep Disorders (UG3/UH3 Clinical Trial Not Allowed)

Thu, 04/04/2019 - 11:18
Funding Opportunity RFA-HL-20-014 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to fund research centers that will establish longitudinal cohorts in rare HLBS diseases to investigate unaddressed research questions using epidemiologic study designs and methods that are appropriate for conditions affecting fewer than 200,000 persons in the US. These observational cohort studies should be designed to provide an evidence base for future interventional studies, including clinical trials; for developing better diagnostics than those that are currently available; for answering early translational questions; or for broader implementation of guidelines for managing these diseases. This program will provide opportunities to advance rare disease research using genetics and deep phenotyping to characterize the disease and to identify disease sub-types; to use data science methods that integrate clinical and patient-reported outcomes (PROs) with laboratory, imaging, environmental and -omics data to understand the natural history of disease; to generate data that differentiate patients with the same morphological phenotype but different genetic mutations and severity of outcomes; to elucidate genotype-phenotype interactions and multisystem phenotyping to develop reliable and valid predictive tools to determine who will respond to which treatments and when to intervene; and to encourage innovative methods such as telemedicine to include participants with rare diseases located in remote locations. This initiative will allow applicants to study related rare diseases, disorders, conditions or syndromes together based on pathogenesis, affected biochemical, cellular or physiological features or organ system involvement. Studying related rare diseases within the same cohort could help understand the nuances, and knowledge gained from one disease and could accelerate the advances in related diseases. For example, investigators may propose to study hemoglobin disorders rather than only sickle cell anemia or thalassemia.
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Clinical Research to Improve the Oral Health of Older Adults (R21 Clinical Trial Not Allowed)

Thu, 04/04/2019 - 11:02
Funding Opportunity PAR-19-240 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate exploratory or developmental research that can help to inform future, targeted interventions to address risk factors, access barriers, oral health promotion and disease prevention strategies, and clinical management of dental, oral, and craniofacial (DOC) diseases associated with aging. Collaborations between researchers focused on aging and researchers focused on DOC health will be strongly encouraged.
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Clinical Research to Improve the Oral Health of Older Adults (R01 Clinical Trial Not Allowed)

Thu, 04/04/2019 - 11:02
Funding Opportunity PAR-19-239 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research to address gaps in our knowledge related to the risk factors, access barriers, oral health promotion and disease prevention strategies, and clinical management of dental, oral, and craniofacial (DOC) diseases associated with aging. To stimulate scientific advances, research supported by this FOA should consider interdisciplinary research and interprofessional approaches focused on improving DOC health in adults age 65 and older. Collaborations between researchers focused on aging and researchers focused on DOC health will be strongly encouraged.
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Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Basic Experimental Studies with Humans Required)

Thu, 04/04/2019 - 10:42
Funding Opportunity RFA-ES-19-008 from the NIH Guide for Grants and Contracts. The NIEHS Revolutionizing Innovative, Visionary Environmental health Research (RIVER) program seeks to provide support for the majority of the independent research program for outstanding investigators in the Environmental Health Sciences, giving them intellectual and administrative freedom, as well as sustained support to pursue their research in novel directions in order to achieve greater impacts. The program seeks to identify individuals, regardless of career stage, with a potential for continued innovative and impactful research and combine their existing investigator-initiated research into a single award with a duration of up to 8 years and direct costs of $600,000 and potentially up to $750,000 based on current NIEHS funding to be consolidated into the award. This funding opportunity is intended for basic experimental studies with humans that aim to understand fundamental aspects of phenomena or observable facts without specific applications towards processes or products in mind. Types of studies that fit within this funding opportunity include those using human subjects to support a deeper understanding of the mechanisms underlying the effects of environmental exposures on human health, including molecular epidemiological studies.
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Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Clinical Trial Not Allowed)

Thu, 04/04/2019 - 10:42
Funding Opportunity RFA-ES-19-007 from the NIH Guide for Grants and Contracts. The NIEHS Revolutionizing Innovative, Visionary Environmental health Research (RIVER) program seeks to provide support for the majority of the independent research program for outstanding investigators in the Environmental Health Sciences, giving them intellectual and administrative freedom, as well as sustained support to pursue their research in novel directions in order to achieve greater impacts. The program seeks to identify individuals, regardless of career stage, with a potential for continued innovative and impactful research and combine their existing investigator-initiated research into a single award with a duration of up to 8 years and direct costs of $600,000 and potentially up to $750,000 based on current NIEHS funding to be consolidated into the award.
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NIH Directors New Innovator Award Program (DP2 Clinical Trial Optional)

Thu, 04/04/2019 - 10:17
Funding Opportunity RFA-RM-19-006 from the NIH Guide for Grants and Contracts. The NIH Directors New Innovator Award Program supports early stage investigators of exceptional creativity who propose highly innovative research projects with the potential to produce a major impact on broad, important problems relevant to the mission of NIH. For the program to support the best possible researchers and research, applications are sought which reflect the full diversity of the research workforce. Individuals from diverse backgrounds and from the full spectrum of eligible institutions in all geographic locations are strongly encouraged to apply to this Funding Opportunity Announcement. In addition, applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. The NIH Director's New Innovator Award Program complements ongoing efforts by NIH and its Institutes and Centers to fund early stage investigators through R01 grants, which continue to be the major sources of NIH support for early stage investigators. The NIH Directors New Innovator Award Program is a component of the High-Risk, High-Reward Research Program of the NIH Common Fund.
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Short-term Mentored Career Enhancement Award in Dental, Oral and Craniofacial Research for Mid-Career and Senior Investigators (K18 Independent Clinical Trial Not Allowed)

Thu, 04/04/2019 - 09:59
Funding Opportunity PAR-19-238 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications for short-term mentored career enhancement (K18) awards in dental, oral and craniofacial research with a focus on behavioral and social sciences, and genetic and genomic research. The intent of this program is to provide mid-career or senior investigators with short-term training in the theories, tools, methods or approaches of another scientific area, in order to enhance their existing research program. Two categories of candidates are targeted: (a) established dental, oral, and craniofacial research investigators who seek training with investigators from another field, in order to enrich their existing dental, oral and craniofacial research program; and (b) established investigators in other fields who seek training with dental, oral and craniofacial research investigators in order to facilitate the introduction of dental, oral and craniofacial research into an existing research program.
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