NIH Funding Opportunities

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Weekly Funding Opportunities and Policy Notices from the National Institutes of Health.
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Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Neuroprotection - Coordinating Center (U24 Clinical Trial Not Allowed)

Mon, 08/06/2018 - 09:13
Funding Opportunity RFA-NS-18-034 from the NIH Guide for Grants and Contracts. Recent advances in endovascular thrombectomy offer a new opportunity to reconsider neuroprotective agents as adjunctive therapies to extend the time window for reperfusion and to improve long-term functional outcome. The purpose of this funding opportunity announcement (FOA) issued by NINDS is to invite applications for the Coordinating Center (CC) for the NIH Stroke Preclinical Assessment Network (SPAN). SPAN will facilitate testing of up to 6 promising neuroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion). The CC will work with the awarded network sites (RFA-NS-18-033) and will provide centralized administrative oversight and coordination of all aspects of the network. If successful, this network will accelerate the identification of the most promising neuroprotective therapies for future pivotal clinical trials and span the gap between preclinical and clinical testing, in a cost-and time-effective fashion.
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Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Neuroprotection (U01 Clinical Trial Not Allowed)

Mon, 08/06/2018 - 09:13
Funding Opportunity RFA-NS-18-033 from the NIH Guide for Grants and Contracts. The goal of this initiative is to accelerate the identification of the most promising neuroprotective therapies, and span the gap between preclinical and clinical testing, by creating a preclinical stroke network to support late stage preclinical parallel testing of promising neuroprotectants to be given prior to or at the time of reperfusion, with clinically relevant long-term outcomes and comorbidities. This approach will help to determine if an intervention can indeed improve outcome as compared to reperfusion alone and/or extend the therapeutic window for reperfusion, in an experimental controlled setting and in a time and cost-effective manner using an adaptive design approach.
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Limited Competition: Additional Sequencing for the Alzheimer's Disease Sequencing Project: Opportunity for Revision Requests for Active Cooperative Agreements (U01 Clinical Trial Not Allowed)

Fri, 08/03/2018 - 11:56
Funding Opportunity PAR-18-890 from the NIH Guide for Grants and Contracts. The National Institute on Aging invites revision applications to ongoing NIA-supported Cooperative Agreements in the area of the genetics of Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD). This Funding Opportunity Announcement (FOA) invites applications specific to sample acquisition, genome wide association studies, whole genome sequencing, quality control checking, variant calling, and data calling that will support the generation of data for the Alzheimer's Disease Sequencing Project Follow-Up Study.
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Limited Competition: Renewal of, and Revisions to, the Alzheimer's Disease Genetics Consortium (U01 Clinical Trial Not Allowed)

Fri, 08/03/2018 - 11:26
Funding Opportunity PAR-18-889 from the NIH Guide for Grants and Contracts. This FOA invites the NIA Alzheimer's Disease Genetics Consortium to submit revision and/or renewal applications in the area of the genetics of Alzheimer's Disease.
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BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional)

Fri, 08/03/2018 - 09:32
Funding Opportunity RFA-MH-19-135 from the NIH Guide for Grants and Contracts. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits and provide insights into cellular interactions that underlie brain function. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways. Clinical intervention with novel cell and circuit specific tools will require extensive focused research designed to remove barriers to delivery of gene therapies. In addition to identification and removal of barriers, the need to specifically target dysfunctional circuitry poses additional challenges. Neuroscience has experienced an impressive influx of exciting new research tools in the past decade, especially since the launch of the BRAIN Initiative. However, the majority of these cutting edge tools have been developed for use in model organisms, primarily rodents, fish and flies. These cutting edge tools, such as viral delivery of genetic constructs, are increasingly adaptable to large brains and more importantly are emerging as potential human therapeutic strategies for brain disorders. A pressing need to develop tools for use in large brains, more directly relevant to the human brain is the focus of this initiative. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Methods to track and monito
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NCI Research Specialist (Laboratory-based Scientist) Award (R50 Clinical Trial Not Allowed)

Thu, 08/02/2018 - 11:30
Funding Opportunity PAR-18-888 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites grant applications for the Research Specialist Award (R50) in any area of NCI-funded cancer research. This FOA is specifically for core/shared resource/central scientific support scientists. The Research Specialist Award is designed to encourage the development of stable research career opportunities for exceptional scientists who want to continue to pursue research within the context of an existing NCI-funded basic, translational, clinical or population science cancer research program, but not serve as independent investigators. These scientists, such as researchers within a core/shared resource/central scientific support, are vital to sustaining the biomedical research enterprise. The Research Specialist Award is intended to provide salary support and sufficient autonomy so that individuals are not solely dependent on NCI grants held by others for career continuity.
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NCI Research Specialist (Core-based Scientist) Award (R50 Clinical Trial Not Allowed)

Thu, 08/02/2018 - 11:30
Funding Opportunity PAR-18-887 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites grant applications for the Research Specialist Award (R50) in any area of NCI-funded cancer research. This FOA is specifically for core/shared resource/central scientific support scientists. The Research Specialist Award is designed to encourage the development of stable research career opportunities for exceptional scientists who want to continue to pursue research within the context of an existing NCI-funded basic, translational, clinical or population science cancer research program, but not serve as independent investigators. These scientists, such as researchers within a core/shared resource/central scientific support, are vital to sustaining the biomedical research enterprise. The Research Specialist Award is intended to provide salary support and sufficient autonomy so that individuals are not solely dependent on NCI grants held by others for career continuity.
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Special Emphasis Notice (SEN): AHRQ Announces Interest in Health Services Research to Address the Opioids Crisis

Thu, 08/02/2018 - 10:35
Notice NOT-HS-18-015 from the NIH Guide for Grants and Contracts
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AHRQ Implementation of the Burden-Reducing Provisions of the 2018 Common Rule

Thu, 08/02/2018 - 10:30
Notice NOT-HS-18-014 from the NIH Guide for Grants and Contracts
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Alzheimer Centers for Discovery of New Medicines (U54 Clinical Trial Not Allowed)

Thu, 08/02/2018 - 10:20
Funding Opportunity RFA-AG-19-010 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites U54 Cooperative Agreement applications aiming to establish multi-component Alzheimer Centers for the Discovery of New Medicines. The overarching purpose of this Centers program is to improve, diversify and reinvigorate the Alzheimers disease (AD) drug development pipeline by accelerating the characterization and experimental validation of next generation therapeutic targets and, integrating the targets into drug discovery campaigns. In addition, this program aims to de-risk potential therapeutics to the point that industry will invest in them, accelerating the delivery of new drugs to AD patients. To this end, the funded Centers will design, develop and disseminate tools that support target enabling packages (TEPs) for the experimental validation of novel, next generation therapeutic targets, including those emanating from the NIA-funded, target discovery programs such as AMP-AD and, initiate early stage drug discovery campaigns against the enabled targets.
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Management of Asthma in Primary Care - Bioinformatics Center (U24 - Clinical Trial Required - Infrastructure)

Thu, 08/02/2018 - 09:45
Funding Opportunity RFA-HL-19-006 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement is to identify and then prospectively evaluate the effectiveness of current practices used by primary healthcare providers to manage patients with asthma. The study will use electronic health record systems to generate and test paradigms for how to best manage asthma in the primary healthcare setting. The Cooperative Agreement awarded through this FOA will support a Clinical Center, which will have primary responsibility for study management, data collection, and conduct of clinical trials. The Clinical Center will work collaboratively with a Bioinformatics Center, funded separately, which will have primary responsibility for data analytical aspects of the study. Overall, the study is intended to identify "best practices", and thereby inform future clinical decisions by primary healthcare providers who care for patients with asthma.
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Management of Asthma in Primary Care - Clinical Center (UG3/UH3 - Clinical Trial Required)

Thu, 08/02/2018 - 09:45
Funding Opportunity RFA-HL-19-005 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement is to identify and then prospectively evaluate the effectiveness of current practices used by primary healthcare providers to manage patients with asthma. Investigators will identify management strategies in current use for primary care of asthma by analyzing electronic health records (EHRs) from a nationally representative sample of patients and then prospectively evaluate the paradigms for management that appear to be most effective through EHR-enabled clinical trials. The Cooperative Agreement awarded through this FOA will support a Clinical Center, comprised of a primary care network (PCN), a data management core (DMC), and a clinical consultation center (CCC).
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Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional)

Thu, 08/02/2018 - 08:46
Funding Opportunity RFA-NS-18-041 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support the discovery of promising candidate biomarkers that will facilitate the development of non-opioid therapeutic options for the treatment of pain conditions. The goal of this FOA is to encourage a biomarker discovery process that will result in the development of pain biomarkers that can withstand rigorous clinical and analytical validation. It is hoped that an increased availability of rigorous biomarkers for pain will facilitate the discovery and development of transformational non-opioid therapeutics for pain.
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New Paradigms in Tissue Communication-from mediators to metabolic function (RC2 Clinical Trials Optional)

Thu, 08/02/2018 - 07:50
Funding Opportunity PAR-18-886 from the NIH Guide for Grants and Contracts. NIDDK utilizes High Impact, Interdisciplinary Science (RC2) grants to support projects that will lay the foundation for new fields of investigation within the mission of NIDDK. The RC2 is envisioned to use an interdisciplinary approach to generate a research resource and/or foster discovery-based or hypothesis-generating science that can have a significant impact on the broader scientific community. This targeted FOA specifically seeks to generate scientific advancements that are focused on identifying new signals and regulatory networks that mediate metabolic cross talks within and between organs that play a role in the development of diabetes and obesity. The interdisciplinary approaches proposed should be designed to foster novel synergies that will accelerate conceptual and technical breakthroughs in science related to metabolic tissue communication.
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Innovations for Healthy Living - Improving Minority Health and Eliminating Health Disparities (R43/R44 - Clinical Trial Optional)

Wed, 08/01/2018 - 09:28
Funding Opportunity RFA-MD-18-009 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) grant applications that propose to develop a product, process or service for commercialization with the aim of improving minority health and/or reducing health disparities in one or more NIH-defined health disparity population groups. Appropriate technologies should be effective, affordable, and culturally acceptable.
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Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional)

Wed, 08/01/2018 - 09:28
Funding Opportunity RFA-MD-18-010 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) grant applications that propose to develop a product, process or service for commercialization with the aim of improving minority health and/or reducing health disparities in one or more NIH-defined health disparity population groups. Appropriate technologies should be effective, affordable, and culturally acceptable.
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Novel Approaches to Safe, Non-Invasive, Real Time Assessment of Human Placenta Development and Function Across Pregnancy (R21 - Clinical Trial Not Allowed)

Wed, 08/01/2018 - 08:50
Funding Opportunity PAR-18-885 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites grant applications that use novel approaches for the development of safe, real-time, non-invasive (or minimally invasive), in vivo methods to assess the development and function of the human placenta across pregnancy.
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Novel Approaches to Safe, Non-Invasive, Real Time Assessment of Human Placenta Development and Function Across Pregnancy (R01 - Clinical Trial Not Allowed)

Wed, 08/01/2018 - 08:50
Funding Opportunity PAR-18-884 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites grant applications that use novel approaches for the development of safe, real-time, non-invasive (or minimally invasive), in vivo methods to assess the development and function of the human placenta across pregnancy.
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Notice of Pre-Application Webinar for the NIH Common Fund Somatic Cell Genome Editing program

Wed, 08/01/2018 - 08:37
Notice NOT-RM-18-020 from the NIH Guide for Grants and Contracts
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