NIH Funding Opportunities

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Weekly Funding Opportunities and Policy Notices from the National Institutes of Health.
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Feasibility and Planning Studies for Development of Specialized Programs of Research Excellence (SPOREs) to Investigate Cancer Health Disparities (P20 Clinical Trial Optional)

Wed, 03/13/2019 - 10:54
Funding Opportunity RFA-CA-19-034 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for development of translational research programs that are focused upon investigating cancer health disparities. The P20 grants will support feasibility and planning activities to build cancer health disparities research programs. It is the expectation that the research programs developed by the P20 awards should be competitive with other applications for a full Specialized Programs of Research Excellence (SPORE), addressing cancer health disparities as a cross-cutting research theme. All applications must propose translational research that will contribute to improved prevention, early detection, diagnosis, and/or treatment of cancers found to disproportionately affect specific racial/ethnic minority populations. Furthermore, all research projects must be focused upon knowledge of human biology with a translational human endpoint proposed. All P20 grants must include a minimum of two well-developed translational research projects, as well as contribute significantly to the development of specialized shared resources core facilities, improved research model systems, and collaborative research activities with other institutions, P20 awardees, and/or current SPORE grantees
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Medical Rehabilitation Research Resource (P2C Clinical Trial Optional)

Wed, 03/13/2019 - 10:20
Funding Opportunity RFA-HD-20-004 from the NIH Guide for Grants and Contracts. This is the renewal of a Funding Opportunity Announcement (FOA), issued by NICHD, NINDS, NIBIB, NIDCD, and NINR, National Institutes of Health, to invite grant applications from institutions/organizations that propose to build a research infrastructure center to promote external collaboration with the medical rehabilitation community. The aim of this FOA is to create a national network of research centers that provide access to collateral expertise in biomedical, behavioral, engineering, and/or psychosocial fields that are particularly relevant to medical rehabilitation research and the needs of people with chronic physical disabilities. Specifically, the NIH is interested in addressing gaps in the rehabilitation research portfolio and is particularly interested in the following high-priority areas: pediatric rehabilitation; personalized medicine approaches; family, caregiver, and community support; implementation and dissemination research; clinical trial design and combinatorial therapies; strategies to explore and validate combination therapies; and, technology to track real-world outcomes.
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Conduct Studies to Establish More Targeted Durations of Use for Certain Approved Antimicrobial New Animal Drugs in Food Animals (U01 Clinical Trial Required)

Wed, 03/13/2019 - 08:53
Funding Opportunity RFA-FD-19-007 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity is to solicit applications to conduct studies that could support the approval of label changes to establish more targeted durations of use for certain approved medically important antimicrobial new animal drugs in food animals. These cooperative agreements are intended to provide publicly available data to be used by sponsor(s) of affected approved new animal drugs to support approval of future supplemental new animal drug applications. Such supplemental new animal drug applications are intended to: 1) Revise approved dosage regimens to provide for use durations that are more targeted (i.e., are more specifically defined) and, 2) That the revised dosage regimens continue to provide effectiveness that is comparable to the currently approved regimen while reducing the risk of antimicrobial resistance development.
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Clinical Trial Readiness for Rare Neurological and Neuromuscular Diseases (U01 Clinical Trial Not Allowed)

Wed, 03/13/2019 - 08:42
Funding Opportunity PAR-19-220 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites researchers to submit applications for support of clinical studies that address critical needs for clinical trial readiness in rare neurological and neuromuscular diseases. These studies should result in clinically validated biomarkers and clinical outcome assessment measures appropriate for use in upcoming clinical trials. Through the support of trial readiness studies, NINDS and NCATS expect to enhance the quality and increase the likelihood of success of clinical trials in these rare diseases.
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Advancing Manufacturing Processing and Control Strategies for Drug Substances and Drug Products (U01)- Clinical Trial Optional

Wed, 03/13/2019 - 07:55
Funding Opportunity PAR-19-216 from the NIH Guide for Grants and Contracts. The goal of this program is to support the advancement of regulatory science to facilitate the implementation and the assessment of continuous manufacturing and similar innovative monitoring and control techniques in the pharmaceutical sector. This will be accomplished by making awards to institutions of higher education and nonprofit organizations for the purpose of studying and recommending improvements to the process of continuous manufacturing of drugs and biological products (e.g., monoclonal antibodies and therapeutic enzymes). Examples of activities could include the development or modification of a novel manufacturing process (e.g., design, scale-up, and/or commercial scale), control method, and/or testing technology. Awards made under this FOA may be funded in part by appropriations received under the 21st Century Cures Act, section 3016.
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Silvio O. Conte Digestive Diseases Research Core Centers (P30 Clinical Trial Optional)

Wed, 03/13/2019 - 01:59
Funding Opportunity RFA-DK-19-004 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK. The purpose of this Centers program is to bring together basic and clinical investigators as a means to enhance communication, collaboration, and effectiveness of ongoing research related to digestive and/or liver diseases. DDRCCs are based on the core concept, whereby shared resources aimed at fostering productivity, synergy, and new research ideas among the funded investigators are supported in a cost-effective manner. Each proposed DDRCC must be organized around a central theme that reflects the focus of the digestive or liver diseases research of the Center members. The central theme must be within the primary mission of NIDDK, and not thematic areas for which other NIH Institutes or Centers are considered the primary source of NIH funding.
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Notice of Change in Application Due Dates for PAR-19-030 "NIDDK Education Program Grants (R25 Clinical Trial Not Allowed)"

Wed, 03/13/2019 - 01:24
Notice NOT-DK-19-011 from the NIH Guide for Grants and Contracts
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Notice of Special Interest in Research on the Health of Sexual and Gender Minority (SGM) Populations

Wed, 03/13/2019 - 01:12
Notice NOT-MD-19-001 from the NIH Guide for Grants and Contracts
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Nutrition Obesity Research Centers (NORCs) (P30 Clinical Trial Optional)

Wed, 03/13/2019 - 01:04
Funding Opportunity RFA-DK-19-002 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications from institutions/organizations that propose to establish core centers that are part of an integrated and existing program of nutrition and/or obesity research. The Nutrition Obesity Research Centers (NORC) program is designed to support and enhance the national research effort in nutrition and obesity. NORCs support three primary research-related activities: Research Core services, a Pilot and Feasibility (P and F) program, and an Enrichment program. All activities pursued by Nutrition Obesity Research Centers are designed to enhance the efficiency, productivity, effectiveness and multidisciplinary nature of research in nutrition and obesity. The NIDDK Nutrition Obesity Research Centers program consists of 12 Centers, each located at outstanding research institutions with documented programs of excellence in nutrition and/or obesity research.
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Administrative Supplement for Research on Bioethical Issues

Tue, 03/12/2019 - 11:03
Funding Opportunity PA-19-217 from the NIH Guide for Grants and Contracts. The NIH Office of Science Policy (OSP) within the Office of the Director (OD) announces the availability of administrative supplements to support research on bioethical issues to develop and evidence base that may inform future policy directions. Applicants may propose to supplement parent awards focused on bioethics or to add a component related to bioethics to a parent award in which bioethics was not the focus. Areas of high priority research include, but are not limited to, the bioethical, legal, and societal implications of the following: New and emerging technology development and use; clinical and non-clinical data sharing; precision and personalized medicine; research privacy and security; learning healthcare systems; crowdsourcing; participant-driven research and consumer generated data; patient/participant representation in research oversight; special and vulnerable population research; individual or community health, treatment, and/or research disparities; issues related to the inclusion of Tribal and American Indian/Alaska Native populations; current and emerging regulatory environments; innovative study design, conduct, management, and oversight; international research; research on stigmatized conditions; historical analyses of bioethics issues; and novel approaches for enhancing bioethics infrastructure and training.
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Notice of Change to PAR-18-030 "NIA Revision and Resubmission Program Project Applications (P01 Clinical Trial Optional)"

Tue, 03/12/2019 - 09:57
Notice NOT-AG-19-009 from the NIH Guide for Grants and Contracts
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Notice of Availability of Administrative Supplements to Promote Data Sharing in Cancer Epidemiology Studies

Tue, 03/12/2019 - 08:35
Notice NOT-CA-19-031 from the NIH Guide for Grants and Contracts
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Implementation of the Animal Feed Regulatory Program Standards (U18 Clinical Trial Not Allowed)

Tue, 03/12/2019 - 01:07
Funding Opportunity RFA-FD-19-021 from the NIH Guide for Grants and Contracts. The intended outcome of this FOA is to advance efforts for a nationally integrated animal food safety system by assisting State animal food regulatory programs to achieve and maintain full implementation of the Animal Feed Regulatory Program Standards (AFRPS). The AFRPS Cooperative agreement will provide funding for State animal food regulatory programs that maintain a FDA animal food safety inspection contract to: Develop and implement the Standards (AFRPS) Enhance animal food safety, and Better direct their regulatory activities at reducing foodborne illness attributed to animal food safety hazards in facilities that manufacture, process, pack, or hold animal food materials/supplies. In addition, this cooperative agreement may provide funding through regulatory animal food programs for accreditation of laboratories that support animal food programs and may pursue initial accreditation or seek to expand scope of accreditation under the international standard ISO/IEC 17025.
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Maximizing Access to Research Careers (T34)

Tue, 03/12/2019 - 00:54
Funding Opportunity PAR-19-219 from the NIH Guide for Grants and Contracts. The goal of the Maximizing Access to Research Careers (MARC) program is to develop a diverse pool of undergraduates who complete their baccalaureate degree, and transition into and complete biomedical, research-focused higher degree programs (e.g., Ph.D. or M.D./Ph.D). This funding opportunity announcement (FOA) provides support to eligible, domestic institutions to develop and implement effective, evidence-based approaches to biomedical training and mentoring that will keep pace with the rapid evolution of the research enterprise. NIGMS expects that the proposed research training programs will incorporate didactic, research, mentoring, and career development elements to prepare trainees for the completion of research-focused higher degree programs in biomedical fields. This program is limited to applications from training programs at research-intensive institutions (i.e., those with a 3-year average of NIH Research Project Grant funding equal to or above $7.5 million total costs).
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Undergraduate Research Training Initiative for Student Enhancement (U-RISE) (T34)

Tue, 03/12/2019 - 00:35
Funding Opportunity PAR-19-218 from the NIH Guide for Grants and Contracts. The goal of the Undergraduate Research Training Initiative for Student Enhancement (U-RISE) program is to develop a diverse pool of undergraduates who complete their baccalaureate degree, and transition into and complete biomedical, research-focused higher degree programs (e.g., Ph.D. or M.D./Ph.D). This funding opportunity announcement (FOA) provides support to eligible, domestic institutions to develop and implement effective, evidence-based approaches to biomedical training and mentoring that will keep pace with the rapid evolution of the research enterprise. NIGMS expects that the proposed research training programs will incorporate didactic, research, mentoring, and career development elements to prepare trainees for the completion of research-focused higher degree programs in biomedical fields. This program is limited to applications from training programs at research-active institutions (i.e., those with a 3-year average of NIH Research Project Grant funding less than $7.5 million total costs).
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Disparities Elimination through Coordinated Interventions to Prevent and Control Heart and Lung Disease Risk (DECIPHeR) - Research Coordinating Center (RCC) (U24 Clinical Trial Not Allowed)

Mon, 03/11/2019 - 11:46
Funding Opportunity RFA-HL-20-004 from the NIH Guide for Grants and Contracts. The National Heart, Lung, and Blood Institute invites applications for a Research Coordinating Center (RCC) to support projects from RFA-HL-20-003 Disparities Elimination through Coordinated Interventions to Prevent and Control Heart and Lung Disease Risk (DECIPHeR), which will test late-stage (T4) implementation research strategies for optimally and sustainably delivering proven-effective, evidence-based multi-level interventions to reduce or eliminate cardiovascular and/or pulmonary health disparities, and that promote and improve population health in high-burden communities (see RFA-HL-20-003). The DECIPHeR RCC will coordinate activities across all of the DECIPHeR projects, including coordinating and managing in-person and virtual network steering committee meetings and working groups; promoting collaboration and communication among investigators and the broader research community; coordinating network outreach activities; promoting skills development in implementation science; and organizing, implementing, and managing a global implementation data safety and monitoring board (DSMB) and providing clinical study and site monitoring for DECIPHeR awards. For the purpose of this FOA, late-stage (T4) implementation research is defined as research to identify strategies to achieve sustainable uptake of proven-effective interventions into routine clinical and public health practice and community-based settings and maximize the positive impact on population health.
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