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Notification of Upcoming Change in Federal-wide Unique Entity Identifier Requirements

NIH Funding Opportunities - Thu, 04/11/2019 - 09:13
Notice NOT-OD-19-098 from the NIH Guide for Grants and Contracts
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Senate set to confirm ex-lobbyist Bernhardt as Interior chief

Yahoo Science News feed latest items - Thu, 04/11/2019 - 09:13

Bernhardt would replace former Montana Congressman Ryan Zinke as the head of the Interior Department, which manages federal and tribal lands and waters and is key to President Donald Trump's efforts to boost domestic crude oil, natural gas and coal production. Republican Senators including Marco Rubio and Rick Scott of Florida have also raised concerns over the Interior Department's looming five-year offshore drilling plan, which could expand drilling into new parts of the U.S. Gulf of Mexico, Atlantic, Pacific and Arctic.


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Lyft Investors Grapple With User Metrics as Uber's IPO Looms

Yahoo Science News feed latest items - Thu, 04/11/2019 - 09:11

“Lyft shares continue to be weak as many investors we have spoken with have worries about Uber’s impending S-1 and roadshow which could be a dark shadow over Lyft’s stock in the near-term,” Wedbush analyst Daniel Ives wrote in a note to clients. Uber is expected to file for its public offering as soon as Thursday, when potential investors would get the first opportunity to pore over hundreds of pages of detailed information on the ride-sharing giant’s business plans.


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4 Vitiligo Treatment Options to Consider

Yahoo Science News feed latest items - Thu, 04/11/2019 - 08:59

The skin condition doesn't necessarily need to be treated, but there are medical options you and your doctor may decide to pursue.


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Israel set to land spacecraft on the moon in first

Yahoo Science News feed latest items - Thu, 04/11/2019 - 08:54

Israel's first spacecraft to the moon was expected to make its historic landing there Thursday and become the only private-sector craft to do so following a mission that has captivated the nation. If it succeeds, Israel would become the fourth country to reach the moon but by far the smallest, with the United States, Russia and China the other three. Israeli Prime Minister Benjamin Netanyahu, fresh off his victory in Tuesday's general election, was expected to watch from the control room in Yehud, near Tel Aviv.


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Late-Stage Implementation Research Addressing Hypertension in Low- and Middle-Income Countries: Scaling Up Proven-Effective Interventions (UG3/UH3 Clinical Trial Optional)

NIH Funding Opportunities - Thu, 04/11/2019 - 08:52
Funding Opportunity RFA-HL-20-005 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks grant applications to optimally and sustainably address late-stage implementation research questions to address scaling up evidence-based interventions at the population level for prevention and management of hypertension in low- and middle-income countries and small island developing states. For the purposes of this FOA, late-stage implementation research is defined as research to identify strategies to achieve sustainable uptake of proven-effective interventions in routine clinical and public health and community-based settings and maximize the positive impact on population health. Each awarded project is to conduct late-stage implementation research in one of six geographical regions (e.g., East Asia and the Pacific; Europe and Central Asia; Latin America and the Caribbean; Middle East and North Africa; South Asia; Sub-Saharan Africa). As a group, awardees will constitute a research alliance for hypertension implementation science research in low-resource settings with capabilities for addressing scale-up of evidence-based interventions at the population level for the prevention and management of hypertension. This program is not intended to support research that can be conducted primarily in and/or by the United States or other high-income institutions that do not meet eligibility criteria. This FOA uses the bi-phasic, milestone driven UG3/UH3 cooperative agreement mechanism. Awards made under this FOA will initially support a two-year milestone-driven needs assessment and planning, with possible transition to an implementation (UH3) phase of up to 4 additional years. Only UG3 projects that meet the scientific milestones and award requirements of the UG3 phase may transition to the UH3 phase. Applications submitted in response to this FOA must address both the UG3 and UH3 phases and are expected to include plans for project management and performance milestones for each phase.
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This superbug is a 'serious global health threat.' Here's what you need to know about Candida auris

Yahoo Science News feed latest items - Thu, 04/11/2019 - 08:44

A drug-resistant superbug, fungus Candida auris, has been deemed by the CDC as “a serious global health threat’’ with 617 cases in the U.S.


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7 Misconceptions About Migraines That Need to Be Dispelled ASAP

Yahoo Science News feed latest items - Thu, 04/11/2019 - 08:30

Like many other "invisible" illnesses, misconceptions about migraines abound. These myths undercut the severity of the illness and leave migraine sufferers feeling invalidated — and this can be dangerous because it's easy to convince ourselves that we're simply overreacting to a "bad headache" and there's no need to seek medical help. Migraines affect 39 million Americans […]


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Millions of Women are Living With 'Invisible Illnesses': Here's What That Means

Yahoo Science News feed latest items - Thu, 04/11/2019 - 08:28

Millions of women who look perfectly healthy on the outside are grappling with chronic conditions that make “normal” life anything but. This is what it’s really like to have an invisible illness.


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Three-person baby born in medical 'revolution'

Yahoo Science News feed latest items - Thu, 04/11/2019 - 07:49

A team of Greek and Spanish doctors announced Thursday the birth of a baby using DNA from three people after a controversial fertility treatment that has provoked intense ethical debate. The team used an egg from the infertile mother, the father's sperm and another woman's egg to conceive the baby boy, transferring genetic material with chromosomes from the mother to the egg of a donor whose own genetic material had been removed in a process its creators hailed as a medical "revolution". Institute of Life president Dr Panagiotis Psathas, stated: "Today, for the first time in the world, a woman's inalienable right to become a mother with her own genetic material became a reality.


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As phones and homes get smarter, so are NASA spacesuits

Yahoo Science News feed latest items - Thu, 04/11/2019 - 07:49

As a part of NASA's Innovative Advanced Concepts program, 18 space tech concepts that "have the potential to transform human and robotic exploration of other worlds" were just awarded "Phase 1" research funding. The primary benefit of this SmartSuit's design will be its dexterity thanks to soft robotics technology.


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3 Huge Questions the Black Hole Image Didn't Answer

Yahoo Science News feed latest items - Thu, 04/11/2019 - 07:37

An international network of radio telescopes has produced the first-ever close-up image of a black hole's shadow, which scientists revealed this morning (April 10). The collaboration, called the Event Horizon Telescope, confirmed decades of predictions of how light would behave around these dark objects, and set the stage for a new era of black hole astronomy."From a scale of zero to amazing, it was amazing," said Erin Bonning, an astrophysicist and black hole researcher at Emory University who was not involved in the imaging effort."That said, it was what I expected," she told Live Science.The announcement, teased for about a week and a half in advance, managed to be both incredibly exciting and almost completely devoid of surprising details or new physics. Physics didn't break down. No unexpected features of black holes were revealed. The image itself was almost a perfect match for illustrations of black holes we're used to seeing in science and pop culture. The big difference is that it's a whole lot blurrier. [9 Weird Facts About Black Holes]There were several important questions related to black holes that remained unresolved, however, Bonning said. How do black holes produce their enormous jets of hot, fast matter?All supermassive black holes have the ability to chew up nearby matter, absorb most of it past their event horizons, and spit the remainder out into space at near light speed in blazing towers astrophysicists call "relativistic jets."And the black hole at the center of Virgo A (also called Messier 87) is notorious for its impressive jets, spewing matter and radiation all over space. Its relativistic jets are so huge that they can fully escape the surrounding galaxy.A 1998 Hubble image shows the relatavistic jet escaping Virgo A. J. A. Biretta et al., Hubble Heritage Team (STScI /AURA), NASAAnd physicists know the broad strokes of how this happens: The material accelerates to extreme speeds as it falls into the black hole's gravity well, then some of it escapes while retaining that inertia. But scientists disagree about the details of how this happens. This image and the associated papers don't yet offer any details.Figuring that out, Bonning said, will be a matter of linking up Event Horizons Telescope observations -- which cover a fairly small amount of space -- with the much bigger images of relativistic jets.While physicists don't yet have answers, she said, there's a good chance that they'll come soon -- especially once the collaboration produces images of its second target: the supermassive black hole Sagittarius A* at the center of our own galaxy, which doesn't produce jets like Virgo A's. Comparing the two images, she said, might offer some clarity. How do general relativity and quantum mechanics fit together?Whenever physicists get together to talk about a really exciting new discovery, you can expect to hear someone suggest that it might help explain "quantum gravity."That's because quantum gravity is the great unknown in physics. For about a century, physicists have worked using two different sets of rules: General relativity, which covers very big things like gravity, and quantum mechanics, which covers very small things. The problem is, those two rulebooks directly contradict one another. Quantum mechanics can't explain gravity, and relativity can't explain quantum behavior.Someday, physicists hope to link the two together in a grand unified theory, likely involving some sort of quantum gravity.And before the announcement today, there was speculation that it might include some breakthrough on the subject. (If general relativity's predictions hadn't been borne out in the image, that would have moved the ball forward.) During a news briefing from the National Science Foundation, Avery Broderick, a physicist at the University of Waterloo in Canada, and a collaborator on the project, suggested those sorts of answers might be coming.But Bonning was skeptical of that claim. This image was entirely unsurprising from a general relativity perspective, so it offered no new physics that might close the gap between the two fields, Bonning said.Still, it's not crazy that people hope for answers from this sort of observation, she said, because the edge of a black hole's shadow brings relativistic forces into tiny, quantum-size spaces."We would expect to see quantum gravity very, very close to the event horizon or very, very early in the early universe [when everything was packed into a tiny space]," she said.But at the still-blurry resolution of Event Horizons Telescope, she said, we aren't likely to find those sorts of effects, even with planned upgrades incoming. Were Stephen Hawking's theories as correct as Einstein's?The physicist Stephen Hawking's greatest early-career contribution to physics was the idea of "Hawking radiation" -- that black holes aren't actually black, but emit small amounts of radiation over time. The result was hugely important, because it showed that once a black hole stops growing, it will start to very slowly shrink from the energy loss.But the Event Horizons Telescope didn't confirm or deny this theory, Bonning said, not that anyone expected it to.Giant black holes like the one in Virgo A, she said, emit only minimal amounts of Hawking radiation compared to their overall size. While our most advanced instruments can now detect the bright lights of their event horizons, there's little chance that they will ever tease out the ultra-dim glow of a supermassive black hole's surface.Those results, she said, will likely come from the tiniest black holes -- theoretical, short-lived objects so small that you might enclose their whole event horizon in your hand. With the opportunity for up-close observations, and much more radiation available compared to their overall size, humans might eventually figure out how to produce or find one and detect its radiation. So what did we actually learn from this image?First, physicists learned that Einstein was right, once again. The edge of the shadow, as far as the Event Horizons Telescope can see, is a perfect circle, just as physicists in the 20th century working with Einstein's equations of general relativity predicted."I don't think anyone should be surprised when yet another test of general relativity passes," Bonning said. "If they had walked on stage and said that general relativity had broken, I would have fallen off my chair."The result with more immediate, practical implications, she said, was that the image enabled scientists to precisely measure the mass of this supermassive black hole, which sits 55 million light-years away at the heart of the Virgo A galaxy. It's 6.5 billion times more massive than our sun.That's a big deal, Bonning said, because it could change the way physicists weigh the supermassive black holes at the hearts of other, more distant or smaller galaxies.Right now, physicists have a pretty precise measurement of the mass of the supermassive black hole at the heart of the Milky Way, Bonning said, because they can watch how its gravity moves individual stars in its neighborhood.> Good morning. Here are a bunch of stars orbiting the Milky Way's central black hole over a period of about 20 years. The star near the center passes within 20 billion km of the bh and reaches speeds of ~3% of the speed of light > Image: ESO/MPE (doi: 10.1038/d41586-018-05825-3) pic.twitter.com/bA7WWu6TeN> > -- Robert McNees (@mcnees) March 28, 2019But in other galaxies, our telescopes can't see the movements of individual stars, she said. So physicists are stuck with rougher measurements: How the black hole's mass influences light coming from different layers of stars in the galaxy, or how its mass influences light coming from different layers of free-floating gas in the galaxy.But those calculations are imperfect, she said."You have to model a very complex system," she said.And the two methods end up producing somewhat different results in every galaxy physicists observe. But at least for the black hole in Virgo A, we now know that one method is correct."Our determination of 6.5 billion solar masses ends up landing right on top of the heavier mass determination from [the light coming from stars]," Sera Markoff, an astrophysicist from the University of Amsterdam and a collaborator on the project said in the news briefing.That doesn't mean that physicists will just move wholesale to that approach for measuring black hole masses, Bonning said. But it does offer an important data point for refining future calculations. * The Biggest Unsolved Mysteries in Physics * The 12 Strangest Objects in the Universe * Stephen Hawking's Most Far-Out Ideas About Black HolesOriginally published on Live Science.


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Parents Are Having Measles Parties and It's As Insane As It Sounds

Yahoo Science News feed latest items - Thu, 04/11/2019 - 07:35

As the number of measles cases skyrockets, some parents have been taking a more dangerous approach to building their kids immunity. The Centers for Disease Control and Prevention recommends children, teens, and adults be up to date on MMR vaccinations.


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Northrop Grumman Wins $3.2B Deal to Build E-2D Hawkeye Jet

Yahoo Science News feed latest items - Thu, 04/11/2019 - 07:30

Northrop Grumman (NOC) secures deal to manufacture 24 E-2D Advanced Hawkeye aircraft.


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Bezos Rebuts Warren's Amazon Breakup Call in Antitrust Defense

Yahoo Science News feed latest items - Thu, 04/11/2019 - 07:16

Last month Senator Elizabeth Warren, a presidential candidate, laid out a detailed plan for breaking up Amazon, Google and Facebook Inc. In her vision, Amazon’s Marketplace should be separated from the rest of the site because she said it “crushes” small businesses. “Third-party sellers are kicking our first-party butt.


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Israeli spacecraft nears moon landing and place in elite lunar club

Yahoo Science News feed latest items - Thu, 04/11/2019 - 07:13

The final maneuver brought the spacecraft into a tight elliptical orbit around the moon, just 15-17 kilometers (9-10.5 miles) from the surface at its closest. The landing is set to begin late on Thursday, with touchdown expected around 10:25 p.m. in Israel (1925 GMT), the Israeli space team said.


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IBS: do you have it, and what are the treatment options?

Yahoo Science News feed latest items - Thu, 04/11/2019 - 07:07

If you’re reading this from the loo, where you have been sitting for 15 minutes, you may already have an inkling about the symptoms of Irritable Bowel Syndrome. It’s the hidden condition that affects at least 1 in 10 of us in the UK, leaving us clutching our stomachs in agony and cursing certain foods.  Unsurprisingly, problems with your gut can affect your mood – and it can be made even worse if you don’t fully understand the problem. That’s why we have created this comprehensive guide to understanding the causes and symptoms of IBS, and how to treat the condition. IBS: What are the symptoms? No two cases of IBS are the same, and people experience different symptoms, with varying triggers. However, the most common symptoms of IBS tend to be: Stomach aches and bloating Diarrhoea Constipation These can last for any amount of time, from a couple of hours in the evening to weeks or even months in the future. Other symptoms you may experience include: Flatulence Incontinence Nausea Backache Tiredness If you think you may have IBS, you should consult your GP. Seek an urgent appointment if you have lost a lot of weight, turned pale, found a hard lump in your stomach, or if you are suffering from shortness of breath and heart palpitations. When you visit the GP, they will talk to you about your symptoms. There is no absolute test for IBS, but they may take a blood test to check for other problems like coeliac disease, which has overlapping symptoms with IBS. At a glance | How do I know if I have coeliac? What causes IBS? There are three common causes of IBS, according to Alison Reid, CEO of The IBS Network. Firstly, the after-effect of a powerful course of antibiotics, as this can unbalance the microbiome and make the bowel more sensitive. Secondly, you can have "post-traumatic IBS" in response to a series of distressing events. Or, finally, the condition may be caused by food poisoning – which is the case for 1 in 10 of IBS sufferers. When you have IBS, your symptoms can be triggered by a combination of diet and lifestyle. Certain foods can upset a sensitive gut, according to Reid. She advises you moderate your intake of: fatty foods, spices, caffeine, alcohol and certain vegetables – especially onions, broccoli, pulses, beans and lentils. These vegetables contain medium chain complex sugars that can’t be absorbed, so ferment in the colon, which causes flatulence and bloating. A common IBS misconception is that it’s all about food intolerance. However, lifestyle factors are important. “Mood plays a big part in it. People’s anxiety and stress levels can cause them to have a sensitive gut,” Reid says. So you could have a bit of broccoli one week and be fine but the next week, if you’ve just had a row with your partner, the same meal could trigger your IBS symptoms. If this is true, then why doesn’t everyone get stomach cramps if they have a chilli when they’re stressed? Not everyone has IBS because we all express stress differently, Reid explains. “Those with IBS express stress through issues in their gut in the same way people get neck ache or migraines.” How can you treat IBS and minimise the symptoms? Unfortunately, there is no magic pill for IBS and no absolute cure. “It’s a long-term condition that people can learn to live well with but it’s about them taking some responsibility to self-manage the condition,” Reid says. Lifestyle changes are essential in learning to live with the symptoms. Cook using fresh vegetables, exercise and make time to relax. Plus avoid overloading on caffeine and alcohol and moderate your intake of fatty and spicy foods. The NHS also advise you don’t eat quickly or skip meals. Invest in a food diary, writing down what you eat each day and whether there are any adverse effects. As IBS is individual to each person, you may find there are other foods you need to avoid. If, however, you find this list seriously restricts your dietary choices, go back to your GP and they may prescribe medication or recommend you to a dietitian. A gut health clinic may be also beneficial, as Telegraph writer Claire Irvin found on her trip to the clinic that changed her life. If stress is your major trigger, you may benefit from mindfulness or Cognitive Behavioural Therapy (CBT), a talking therapy that helps to relieve anxiety. One recent study followed 558 serious IBS sufferers who were either put on a programme of CBT or received standard care. Researchers found that patients in the CBT group were more likely to have experienced significant improvement in their symptoms after a year. They also reported a lower level of IBS's impact on their work and daily life. Support groups can also be beneficial to your mental health, to reassure you that you’re not alone in this condition - find a group through The IBS Network.


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U.S. presidential hopeful Warren proposes new corporate profits tax

Yahoo Science News feed latest items - Thu, 04/11/2019 - 07:02

Companies would not pay the new tax, which would be in addition to existing corporate taxes that companies already pay, on their first $100 million in profits. Warren hopes to challenge Republican President Donald Trump, who has focused on tax cuts for corporations, which he says have allowed the economy to flourish and lowered the unemployment rate. Warren's new tax, which she dubs the "Real Corporate Profits Tax," would account for profits U.S. companies make globally and would also be imposed on foreign companies doing substantial work in the United States.


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UFO Fund Shuns Little Green Men to Buy Satellites and Rockets

Yahoo Science News feed latest items - Thu, 04/11/2019 - 07:00

Procure Holdings is starting the first exchange-traded fund that invests solely in the final frontier. The Procure Space ETF, ticker UFO, will start trading in New York on Thursday, the company said in a statement. The fund will track the S-Network Space Index, which holds companies that generate a sizable part of their revenue from satellite technology and other out-of-this-world industries.


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Viking Therapeutics Jumps as New Liver Drug Gets Positive Results

Yahoo Science News feed latest items - Thu, 04/11/2019 - 06:52

Seven of nine patients getting Viking’s VK2809 at a dose of 5 milligrams once a day saw their liver fat cut by 50 percent or more. The biggest reduction in liver fat at the 5 milligram dose was 78 percent, according to data presented at the European Association for the Study of the Liver congress in Vienna. The company is also testing a 10 milligram dose.


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