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Immune Tolerance Network (UM1 Clinical Trial Required)

NIH Funding Opportunities - 4 hours 27 min ago
Funding Opportunity RFA-AI-19-068 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Immune Tolerance Network. The major goal of this Network is to develop tolerogenic approaches for the treatment and prevention of disease in three clinical areas: asthma and allergic diseases; autoimmune diseases; and immune-mediated consequences of allotransplantation. The scope of research to be carried out includes: 1) the design and conduct of clinical trials at all phases to evaluate the safety and efficacy of investigational products and approaches for the induction and maintenance of immune tolerance in humans; 2) the design and conduct of mechanistic studies and the development of tolerance assays as integral components of the clinical trials undertaken, including establishing and directing a consortium of laboratories; and one or more biospecimen repositories, and 3) the provision of bioinformatics, data collection, validation and analysis resources. In addition, on a limited basis, the Network may support focused product development and nonclinical studies (e.g., toxicology, pharmacology, pharmacokinetics, etc.) essential for the subsequent evaluation of promising tolerance induction approaches in humans.
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Weak Arctic ice sees 56 polar bears descend on Russian village

More than 50 polar bears have gathered on the edge of a village in Russia's far north, environmentalists and residents said, as weak Arctic ice leaves them unable to roam. The Russian branch of the World Wildlife Fund said climate change was to blame, as unusually warm temperatures prevented coastal ice from forming. The WWF said 56 polar bears had gathered in a one-square-kilometre (0.4-square-mile) area near the village of Ryrkaipy in Chukotka on the northeastern tip of Russia.

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British Woman Revived by Doctors After Her Heart Stopped for 6 Hours: 'It's Like a Miracle'

British Woman Revived by Doctors After Her Heart Stopped for 6 Hours

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Vessel, the $200 million art installation at New York's Hudson Yards, just won a major prize. Here's what it's like to climb it.

The honeycomb-like structure, designed by architect Thomas Heatherwick, was recently honored at the World Architecture Festival.

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A YouTuber launched a viral campaign to plant 20 million trees by 2020. Here's the list of prominent people who have donated, including Elon Musk, Jeffree Star, and even the CEO of YouTube.

Here are the biggest names in tech and YouTube who donated to the TeamTrees cause, including Tesla CEO Elon Musk, PewDiePie, and Jeffree Star.

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Our cell phones are causing more head and neck injuries, study shows

A study looking at 20 years of emergency room data found that head and neck injuries have been on the rise, with a sharp increase occurring in 2007.

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Disappearing frontier: Alaska's glaciers retreating at record pace

Alaska will soon close a year that is shaping up as its hottest on record, with glaciers in the "Frontier State" melting at record or near-record levels, pouring waters into rising global seas, scientists said after taking fall measurements. Lemon Creek Glacier in Juneau, where records go back to the 1940s, had its second consecutive year of record mass loss, with 3 meters erased from the surface, U.S. Geological Survey glaciologist Louis Sass told Reuters. Melt went all the way up to the summit, said Sass, one of the experts who travel to benchmark glaciers to take measurements in the fall.

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Clamor as Greta Thunberg joins climate activists in Madrid

Yahoo Science News feed latest items - 13 hours 40 min ago

Climate activist Greta Thunberg said Friday that calls for real action against climate change are still being “ignored" by political leaders despite their continuous praise of the global environmental youth movement she helped create. The Swedish teen was in Madrid, where United Nations-sponsored talks on climate change are underway, to join fellow young climate activists, representatives of Latin America's indigenous peoples, and thousands of other protesters. Thunberg took part in a huge evening protest march through central Madrid.

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An experiment that solved a 100-year-old mystery posed by Einstein just got up to 50% more powerful by squeezing light

Yahoo Science News feed latest items - Thu, 12/05/2019 - 16:35

LIGO can now detect gravitational waves almost every week, thanks to a new instrument that squeezes photons in a vacuum.

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You just lived through the warmest decade on record – and it's only going to get hotter

Yahoo Science News feed latest items - Thu, 12/05/2019 - 14:32

And 2019 is on course to be the second- or third-warmest year on record, with 2016 still holding the all-time temperature record.

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SpaceX launches Dragon cargo craft with mighty mice and a tricky shipment for Seattle’s Spaceflight

Yahoo Science News feed latest items - Thu, 12/05/2019 - 11:47

A fresh SpaceX Falcon 9 rocket launched a recycled robotic Dragon cargo capsule today, carrying 5,700 pounds of supplies, satellites and science to the International Space Station. In contrast with Wednesday's planned launch attempt, which was called off due to excessively high upper-level winds, today's countdown proceeded smoothly to liftoff at 12:29 p.m. ET (9:29 a.m. PT) from Cape Canaveral Air Force Station in Florida. Minutes after launch, the Falcon 9's first stage fell away as planned and flew itself back for touchdown on a drone ship stationed hundreds of miles out in the Atlantic Ocean. SpaceX went with an… Read More

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Emotional Well-Being: High-Priority Research Networks (U24, Clinical Trial Optional)

NIH Funding Opportunities - Thu, 12/05/2019 - 08:49
Funding Opportunity RFA-AT-20-003 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications that focus on developing resources by refining and testing key concepts that will advance and further support the study of emotional well-being in the field at large. This infrastructure support will facilitate research networks through meetings, conferences, small-scale pilot research, multidisciplinary cross training (such as intensive workshops, summer institutes, or visiting scholar programs), and information dissemination to foster the growth and development of research in the following priority areas: (1) Ontology and measurement of emotional well-being; (2) Mechanistic research on the role of emotional well-being in health; (3) Biomarkers of emotional well-being; (4) Prevention research (mechanisms-focused intervention development in target populations); (5) Technology and outcome measure development for mechanistic studies; (6) Development and validation of well-being measures.
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Novartis is tapping AWS to revamp manufacturing processes with AI and data analytics

Yahoo Science News feed latest items - Thu, 12/05/2019 - 08:29

Novartis strikes a multiyear deal with AWS to leverage artificial intelligence and data analytics to revamp the steps involved in drug manufacturing.

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