Margaret E. Rice, Ph.D.

Research in Dr. Rice's laboratory is focused on regulation of dopamine, a key transmitter in motor and reward pathways in the brain. Current research is centered on a novel finding from the Rice group that hydrogen peroxide (H2O2), produced by mitochondrial respiration, is an endogenous regulator of synaptic and somatodendritic dopamine release, as well as dopamine neuron activity in the substantia nigra. The Rice group also studies regulation of axonal dopamine release by glutamate, GABA, calcium, cannabinoids and caffeine, the mechanism and regulation of somatodendritic dopamine release, and dopamine dysfunction in transgenic mouse models of dystonia and PD.

Lab location: 
Public Health Lab, Floor 8, 455 First Avenue
Last name: 
Rice